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enzyme (lysozyme)

 
Enzymes
  Enzyme classes:
  EC 1: Oxidoreductases
    EC 1.1
    EC 1.2
    EC 1.3
    EC 1.4
    EC 1.5
      EC 1.5.1
        EC 1.5.1.1
        EC 1.5.1.2
        EC 1.5.1.3
        EC 1.5.1.4
        EC 1.5.1.5
        EC 1.5.1.6
        EC 1.5.1.7
        EC 1.5.1.8
        EC 1.5.1.9
        EC 1.5.1.10
        EC 1.5.1.11
        EC 1.5.1.12
        EC 1.5.1.13
        EC 1.5.1.14
        EC 1.5.1.15
        EC 1.5.1.16
        EC 1.5.1.17
        EC 1.5.1.18
        EC 1.5.1.19
        EC 1.5.1.20
        EC 1.5.1.21
        EC 1.5.1.22
        EC 1.5.1.23
        EC 1.5.1.24
        EC 1.5.1.25
        EC 1.5.1.26
        EC 1.5.1.27
        EC 1.5.1.28
        EC 1.5.1.29
        EC 1.5.1.30
        EC 1.5.1.31
        EC 1.5.1.32
        EC 1.5.1.33
        EC 1.5.1.34
        EC 1.5.1.35
      EC 1.5.3
      EC 1.5.4
      EC 1.5.7
      EC 1.5.8
      EC 1.5.99
    EC 1.6
    EC 1.7
    EC 1.8
    EC 1.9
    EC 1.10
    EC 1.11
    EC 1.12
    EC 1.13
    EC 1.14
    EC 1.15
    EC 1.16
    EC 1.17
    EC 1.18
    EC 1.19
    EC 1.20
    EC 1.21
    EC 1.97
    EC 1.98
    EC 1.99
  EC 2: Transferases
  EC 3: Hydrolases
  EC 4: Lyases
  EC 5: Isomerases
  EC 6: Ligases
  General information:
  Catalytic mechanism
  Enzyme kinetics
  Inhibitors
  Enzymes in industry

EC 1.5.1.3 - 5,6,7,8- tetrahydrofolate:NADP + oxidoreductase (dihydrofolate reductase)



3D structures of EC 1.5.1.3 - dihydrofolate reductase in Protein Data Bank

updated: 17 May 2012, 1:59

In total: 271 PDB structures of EC 1.5.1.3 - dihydrofolate reductase:
  1. 1ai9: Candida Albicans Dihydrofolate Reductase
  2. 1ao8: Dihydrofolate Reductase Complexed with Methotrexate, Nmr, 21 Structures
  3. 1aoe: Candida Albicans Dihydrofolate Reductase Complexed with Dihydro-nicotinamide-adenine-dinucleotide Phosphate (nadph) and 1,3-diamino-7-(1-ethyepropye)-7h-pyrralo-[3,2- F]quinazoline (gw345)
  4. 1boz: Structure-based Design and Synthesis of Lipophilic 2,4- Diamino-6-substituted Quinazolines and Their Evaluation as Inhibitors of Dihydrofolate Reductase and Potential Antitumor Agents
  5. 1bzf: Nmr Solution Structure and Dynamics of The Complex of Lactobacillus Casei Dihydrofolate Reductase with The New Lipophilic Antifolate Drug Trimetrexate, 22 Structures
  6. 1cd2: Ligand Induced Conformational Changes in The Crystal Structures of Pneumocystis Carinii Dihydrofolate Reductase Complexes with Folate and Nadp+
  7. 1cz3: Dihydrofolate Reductase from Thermotoga Maritima
  8. 1d1g: Dihydrofolate Reductase from Thermotoga Maritima
  9. 1daj: Comparison of Ternary Complexes of Pneumocystis Carinii and Wild Type Human Dihydrofolate Reductase with Coenzyme Nadph and a Novel Classical Antitumor Furo[2,3d]pyrimidine Antifolate
  10. 1ddr: Molecule: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with Methotrexate and Urea
  11. 1dds: Molecule: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with Methotrexate
  12. 1df7: Dihydrofolate Reductase of Mycobacterium Tuberculosis Complexed with Nadph and Methotrexate
  13. 1dg5: Dihydrofolate Reductase of Mycobacterium Tuberculosis Complexed with Nadph and Trimethoprim
  14. 1dg7: Dihydrofolate Reductase of Mycobacterium Tuberculosis Complexed with Nadph and 4-bromo Wr99210
  15. 1dg8: Dihydrofolate Reductase of Mycobacterium Tuberculosis Complexed with Nadph
  16. 1dhf: Crystal Structures of Recombinant Human Dihydrofolate Reductase Complexed with Folate and 5-deazofolate
  17. 1dhi: Long-range Structural Effects in a Second-site Revertant of a Mutant Dihydrofolate Reductase
  18. 1dhj: Long-range Structural Effects in a Second-site Revertant of a Mutant Dihydrofolate Reductase
  19. 1dis: Dihydrofolate Reductase (e.c.1.5.1.3) Complex with Brodimoprim-4,6-dicarboxylate
  20. 1diu: Dihydrofolate Reductase (e.c.1.5.1.3) Complex with Brodimoprim-4,6-dicarboxylate
  21. 1dlr: Methotrexate-resistant Variants of Human Dihydrofolate Reductase with Substitution of Leucine 22: Kinetics, Crystallography and Potential as Selectable Markers
  22. 1dls: Methotrexate-resistant Variants of Human Dihydrofolate Reductase with Substitution of Leucine 22: Kinetics, Crystallography and Potential as Selectable Markers
  23. 1dr1: 2.2 Angstroms Crystal Structure of Chicken Liver Dihydrofolate Reductase Complexed with Nadp+ and Biopterin
  24. 1dr2: 2.3 Angstroms Crystal Structure of Chicken Liver Dihydrofolate Reductase Complexed with Thionadp+ and Biopterin
  25. 1dr3: 2.3 Angstroms Crystal Structure of Chicken Liver Dihydrofolate Reductase Complexed with Thionadp+ and Biopterin
  26. 1dr4: Crystal Structures of Organomercurial-activated Chicken Liver Dihydrofolate Reductase Complexes
  27. 1dr5: Crystal Structures of Organomercurial-activated Chicken Liver Dihydrofolate Reductase Complexes
  28. 1dr6: Crystal Structures of Organomercurial-activated Chicken Liver Dihydrofolate Reductase Complexes
  29. 1dr7: Crystal Structures of Organomercurial-activated Chicken Liver Dihydrofolate Reductase Complexes
  30. 1dra: Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-induced Conformational Changes and Cooperativity in Binding
  31. 1drb: Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-induced Conformational Changes and Cooperativity in Binding
  32. 1dre: Dihydrofolate Reductase Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  33. 1drf: Crystal Structure of Human Dihydrofolate Reductase Complexed with Folate
  34. 1drh: Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-dideazatetrahydrofolate: Mechanistic Implications
  35. 1dyh: Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-dideazatetrahydrofolate: Mechanistic Implications
  36. 1dyi: Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-dideazatetrahydrofolate: Mechanistic Implications
  37. 1dyj: Isomorphous Crystal Structures of Escherichia Coli Dihydrofolate Reductase Complexed with Folate, 5- Deazafolate and 5,10-dideazatetrahydrofolate: Mechanistic Implications
  38. 1dyr: The Structure of Pneumocystis Carinii Dihydrofolate Reductase to 1.9 Angstroms Resolution
  39. 1e26: Design, Synthesis and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent.
  40. 1hfp: Comparison of Ternary Crystal Complexes of Human Dihydrofolate Reductase with Nadph and a Classical Antitumor Furopyrimdine
  41. 1hfq: Comparison of Ternary Crystal Complexes of Human Dihydrofolate Reductase with Nadph and a Classical Antitumor Furopyrimdine
  42. 1hfr: Comparison of Ternary Crystal Complexes of Human Dihydrofolate Reductase with Nadph and a Classical Antitumor Furopyrimdine
  43. 1ia1: Candida Albicans Dihydrofolate Reductase Complexed with Dihydro-nicotinamide-adenine-dinucleotide Phosphate (nadph) and 5-(phenylsulfanyl)-2,4-quinazolinediamine (gw997)
  44. 1ia2: Candida Albicans Dihydrofolate Reductase Complexed with Dihydro-nicotinamide-adenine-dinucleotide Phosphate (nadph) and 5-[(4-methylphenyl)sulfanyl]-2,4- Quinazolinediamine (gw578)
  45. 1ia3: Candida Albicans Dihydrofolate Reductase Complex in Which The Dihydronicotinamide Moiety of Dihydro-nicotinamide- Adenine-dinucleotide Phosphate (nadph) Is Displaced by 5- [(4-tert-butylphenyl)sulfanyl]-2,4-quinazolinediamine (gw995)
  46. 1ia4: Candida Albicans Dihydrofolate Reductase Complex in Which The Dihydronicotinamide Moiety of Dihydro-nicotinamide- Adenine-dinucleotide Phosphate (nadph) Is Displaced by 5- {[4-(4-morpholinyl)phenyl]sulfanyl}-2,4-quinazolinediamin (gw2021)
  47. 1j3i: Wild-type Plasmodium Falciparum Dihydrofolate Reductase- Thymidylate Synthase (pfdhfr-ts) Complexed with Wr99210, Nadph, and Dump
  48. 1j3j: Double Mutant (C59R+S108N) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase (pfdhfr-ts) Complexed with Pyrimethamine, Nadph, and Dump
  49. 1j3k: Quadruple Mutant (N51I+C59R+S108N+I164L) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase (pfdhfr-ts) Complexed with Wr99210, Nadph, and Dump
  50. 1jol: The Crystal Structure of The Binary Complex between Folinic Acid (leucovorin) and E. Coli Dihydrofolate Reductase
  51. 1jom: The Crystal Structure of The Binary Complex between Folinic Acid (leucovorin) and E. Coli Dihydrofolate Reductase
  52. 1juv: Crystal Structure Analysis of Dihydrofolate Reductase from Bacteriophage T4
  53. 8dfr: Refined Crystal Structures of Chicken Liver Dihydrofolate Reductase. 3 Angstroms Apo-enzyme and 1.7 Angstroms Nadph Holo-enzyme Complex
  54. 7dfr: Crystal Structures of Escherichia Coli Dihydrofolate Reductase. The Nadp+ Holoenzyme and The Folate(dot)nadp+ Ternary Complex. Substrate Binding and a Model for The Transition State
  55. 6dfr: Crystal Structures of Escherichia Coli Dihydrofolate Reductase. The Nadp+ Holoenzyme and The Folate(dot)nadp+ Ternary Complex. Substrate Binding and a Model for The Transition State
  56. 5dfr: Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-induced Conformational Changes and Cooperativity in Binding
  57. 4dfr: Crystal Structures of Escherichia Coli and Lactobacillus Casei Dihydrofolate Reductase Refined at 1.7 Angstroms Resolution. I. General Features and Binding of Methotrexate
  58. 4cd2: Ligand Induced Conformational Changes in The Crystal Structures of Pneumocystis Carinii Dihydrofolate Reductase Complexes with Folate and Nadp+
  59. 1klk: Crystal Structure of Pneumocystis Carinii Dihydrofolate Reductase Ternary Complex with Pt653 and Nadph
  60. 1kms: Human Dihydrofolate Reductase Complexed with Nadph and 6- ([5-quinolylamino]methyl)-2,4-diamino-5-methylpyrido[2,3- D]pyrimidine (sri-9439), a Lipophilic Antifolate
  61. 1kmv: Human Dihydrofolate Reductase Complexed with Nadph and (z)- 6-(2-[2,5-dimethoxyphenyl]ethen-1-yl)-2,4-diamino-5- Methylpyrido[2,3-d]pyrimidine (sri-9662), a Lipophilic Antifolate
  62. 3nxv: Preferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for The E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as Ternary Complexes with Nadph and Human Dihydrofolate Reductase
  63. 3nxt: Preferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for The E-and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2m,3-d]pyrimidines as Ternary Complexes with Nadph and Human Dihydrofolate Reductase
  64. 3nxr: Perferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for The E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as Ternary Complexes with Nadph and Human Dihydrofolate Reductase
  65. 3nxo: Perferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for The E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as Ternary Complexes with Nadph and Human Dihydrofolate Reductase
  66. 1lud: Solution Structure of Dihydrofolate Reductase Complexed with Trimethoprim and Nadph, 24 Structures
  67. 1ly3: Analysis of Quinazoline and Pyridopyrimidine N9-c10 Reversed Bridge Antifolates in Complex with Nadp+ and Pneumocystis Carinii Dihydrofolate Reductase
  68. 1ly4: Analysis of Quinazoline and Pyrido[2,3d]pyrimidine N9-c10 Reversed Bridge Antifolates in Complex with Nadp+ and Pneumocystis Carinii Dihydrofolate Reductase
  69. 1m78: Candida Albicans Dihydrofolate Reductase Complexed with Dihydro-nicotinamide-adenine-dinucleotide Phosphate (nadph) and 5-chloryl-2,4,6-quinazolinetriamine (gw1225)
  70. 1m79: Candida Albicans Dihydrofolate Reductase Complexed with Dihydro-nicotinamide-adenine-dinucleotide Phosphate (nadph) and 5-(4-methoxyphenoxy)-2,4-quinazolinediamine (gw1466)
  71. 1m7a: Candida Albicans Dihydrofolate Reductase Complexed with Dihydro-nicotinamide-adenine-dinucleotide Phosphate (nadph) and 7-[2-methoxy-1-(methoxymethyl)ethyl]-7h- Pyrrolo[3,2-f] Quinazoline-1,3-diamine (gw557)
  72. 1mvs: Analysis of Two Polymorphic Forms of a Pyrido[2,3- D]pyrimidine N9-c10 Reverse-bridge Antifolate Binary Complex with Human Dihydrofolate Reductase
  73. 1mvt: Analysis of Two Polymorphic Forms of a Pyrido[2,3- D]pyrimidine N9-c10 Reverse-bridge Antifolate Binary Complex with Human Dihydrofolate Reductase
  74. 3m09: F98Y Tmp-resistant Dihydrofolate Reductase from Staphylococcus Aureus with Inhibitor Rab1
  75. 3m08: Wild Type Dihydrofolate Reductase from Staphylococcus Aureus with Inhibitor Rab1
  76. 3lg4: Staphylococcus Aureus V31Y, F92I Mutant Dihydrofolate Reductase Complexed with Nadph and 5-[(3s)-3-(5-methoxy-2',6'-dimethylbiphenyl- 3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
  77. 3kjs: Crystal Structure of T. Cruzi Dhfr-ts with 3 High Affinity Dhfr Inhibitors: Dq1 Inhibitor Complex
  78. 1ohj: Human Dihydrofolate Reductase, Monoclinic (p21) Crystal Form
  79. 1ohk: Human Dihydrofolate Reductase, Orthorhombic (p21 21 21) Crystal Form
  80. 3k74: Disruption of Protein Dynamics by an Allosteric Effector Antibody
  81. 3k47: Alternate Binding Modes Observed for The E- and Z-isomers of 2,4- Diaminofuro[2,3-d]pyrimidines as Ternary Complexes with Nadph and Mouse Dihydrofolate Reductase
  82. 3k45: Alternate Binding Modes Observed for The E- and Z-isomers of 2,4- Diaminofuro[2,3d]pyrimidines as Ternary Complexes with Nadph and Mouse Dihydrofolate Reductase
  83. 3jwm: Crystal Structure of Bacillus Anthracis Dihydrofolate Reductase Complexed with Nadph and (s)-2,4-diamino-5-(3-methoxy-3-(3,4,5- Trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (UCP114A)
  84. 3jwk: Crystal Structure of Bacillus Anthracis (Y102F) Dihydrofolate Reductase Complexed with Nadph and (s)-2,4-diamino-5-(3-methoxy-3-(3, 4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (UCP114A)
  85. 3jwf: Crystal Structure of Bacillus Anthracis (Y102F) Dihydrofolate Reductase Complexed with Nadph and (r)-2,4-diamino-5-(3-hydroxy-3-(3, 4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (UCP113A)
  86. 3jwc: Crystal Structure of Bacillus Anthracis (Y102F) Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-(3-(3,4,5- Trimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120A)
  87. 3jw5: Crystal Structure of Bacillus Anthracis (Y102F) Dihydrofolate Reductase Complexed with Nadph and Trimethoprim
  88. 3jw3: Crystal Structure of Bacillus Anthracis (F96I) Dihydrofolate Reductase Complexed with Nadph and Trimethoprim
  89. 3jvx: Crystal Structure of Bacillus Anthracis Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl) Prop-1-ynyl)-6-ethylpyrimidine (UCP120A)
  90. 3jsu: Quadruple MUTANT(N51I+C59R+S108N+I164L) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase(pfdhfr-ts) Complexed with Qn254, Nadph, and Dump
  91. 3ix9: Crystal Structure of Streptococcus Pneumoniae Dihydrofolate Reductase - Sp9 Mutant
  92. 1pd8: Analysis of Three Crystal Structure Determinations of a 5- Methyl-6-n-methylanilino Pyridopyrimidine Antifolate Complex with Human Dihydrofolate Reductase
  93. 1pd9: Analysis of Three Crystal Structure Determinations of a 5- Methyl-6-n-methylanilino Pyridopyrimidine Antifolate Complex with Human Dihydrofolate Reductase
  94. 1pdb: Analysis of Three Crystal Structure Determinations of a 5- Methyl-6-n-methylanilino Pyridopyrimidine Antifolate Complex with Human Dihydrofolate Reductase
  95. 3iro: Trypanosoma Cruzi Dihydrofolate Reductase-thymidylate Synthase Complexed with Nadph and Q-8 Antifolate
  96. 3irn: Trypanosoma Cruzi Dihydrofolate Reductase-thymidylate Synthase Complexed with Nadph and Cycloguanil
  97. 3irm: Trypanosoma Cruzi Dihydrofolate Reductase-thymidylate Synthase Complexed with Cycloguanil
  98. 3inv: Trypanosoma Cruzi Dihydrofolate Reductase-thymidylate Synthase Complexed with Nadph, Dump and C-448 Antifolate
  99. 3ia5: Moritella Profunda Dihydrofolate Reductase (dhfr)
  100. 3ia4: Moritella Profunda Dihydrofolate Reductase (dhfr) in Complex with Nadph and Methotrexate (mtx)
  101. 3i8a: Staphylococcus Aureus H30N, F98Y Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-(3-(2,5- Dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)
  102. 3hbb: Structures of Dihydrofolate Reductase-thymidylate Synthase of Trypanosoma Cruzi in The Folate-free State and in Complex with Two Antifolate Drugs, Trimetrexate and Methotrexate
  103. 1qzf: Crystal Structure of Dhfr-ts from Cryptosporidium Hominis
  104. 3gyf: Human Dhfr with Z-isomer in Orthorhombic Lattice
  105. 1ra1: Dihydrofolate Reductase Complexed with Nicotinamide Adenine Dinucleotide Phosphate (reduced Form)
  106. 1ra2: Dihydrofolate Reductase Complexed with Folate and Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  107. 1ra3: Dihydrofolate Reductase Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  108. 1ra8: Dihydrofolate Reductase Complexed with Folate and 2- Monophosphoadenosine 5'-diphosphoribose
  109. 1ra9: Dihydrofolate Reductase Complexed with Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  110. 1rb2: Dihydrofolate Reductase Complexed with Folate and Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  111. 1rb3: Dihydrofolate Reductase Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  112. 1rc4: Dihydrofolate Reductase Complexed with 5,10- Dideazatetrahydrofolate and Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  113. 1rd7: Dihydrofolate Reductase Complexed with Folate
  114. 1re7: Dihydrofolate Reductase Complexed with Folate
  115. 1rf7: Structure of Dihydrofolate Reductase Complexed with Dihydrofolate
  116. 1rg7: Dihydrofolate Reductase Complexed with Methotrexate
  117. 1rh3: Dihydrofolate Reductase Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (reduced Form)
  118. 3gi2: Human Dihydrofolate Reductase Q35K Mutant Inhibitor Complex
  119. 3ghw: Human Dihydrofolate Reductase Inhibitor Complex
  120. 3ghv: Human Dihydrofolate Reductase Q35K/N64F Double Mutant Inhibitor Complex
  121. 3ghc: Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-amino-4-oxo-5-substituted-6-thieno[2,3- D]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agenst
  122. 1rx1: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with Nicotinamide Adenine Dinucleotide Phosphate (reduced Form)
  123. 1rx2: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with with Folate and Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  124. 1rx3: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with Methotrexate and Nicotinamide Adenine Dinucleotide Phosphate (reduced Form)
  125. 1rx4: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with 5,10- Dideazatetrahydrofolate and 2'-monophosphoadenosine 5'- Diphosphoribose
  126. 1rx5: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with 5,10- Dideazatetrahydrofolate
  127. 1rx6: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with 5,10- Dideazatetrahydrofolate and Nicotinamide Adenine Dinucleotide Phosphate (reduced Form)
  128. 1rx7: Structure of Dihydrofolate Reductase Complexed with Folate
  129. 1rx8: Dihydrofolate Reductase Complexed with Folate and 2'- Monophosphoadenosine 5'-diphosphoribose
  130. 1rx9: Dihydrofolate Reductase (e.c.1.5.1.3) Complexed with Nicotinamide Adenine Dinucleotide Phosphate (oxidized Form)
  131. 1s3u: Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis Carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
  132. 1s3v: Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis Carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
  133. 1s3w: Structure Determination of Tetrahydroquinazoline Antifoaltes in Complex with Human and Pneumocystis Carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
  134. 1s3y: Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis Carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
  135. 3fyw: Staph. Aureus Dhfr Complexed with Nadph and Ar-101
  136. 3fyv: Staph. Aureus Dhfr Complexed with Nadph and Ar-102
  137. 3fy9: Staph. Aureus Dhfr F98Y Complexed with Ar-102
  138. 3fy8: Crystal Structure of Staph. Aureus Dhfr Complexed with Nadph and Ar-101
  139. 3fs6: Correlations of Inhibitor Kinetics for Pneumocystis Jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes
  140. 3frf: S. Aureus Dhfr Complexed with Nadph and Iclaprim
  141. 3fre: S. Aureus Dhfr Complexed with Nadph and Tmp
  142. 3frd: S. Aureus Dhfr Complexed with Nadph and Folate
  143. 3frb: S. Aureus F98Y Dhfr Complexed with Tmp
  144. 3fra: Staphylococcus Aureus F98Y Dhfr Complexed with Iclaprim
  145. 3fqz: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3-methoxy-4-phenylphenyl) But-1-ynyl]-6-methylpyrimidine
  146. 3fqv: Staphylococcus Aureus F98Y Mutant Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3-methoxy-4- Phenylphenyl)but-1-ynyl]-6-methylpyrimidine
  147. 3fqo: Staphylococcus Aureus F98Y Mutant Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(2,5- Dimethoxyphenyl)prop-1-ynyl]-6-ethylpyrimidine (UCP120B)
  148. 3fqf: Staphylococcus Aureus F98Y Mutant Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3,4,5- Trimethoxyphenyl)pent-1-ynyl]-6-methylpyrimidine (UCP115A)
  149. 3fqc: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3,4,5-trimethoxyphenyl) Pent-1-ynyl]-6-methylpyrimidine (UCP115A)
  150. 3fq0: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop- 1-ynyl)-6-ethylpyrimidine (UCP120B)
  151. 1sej: Crystal Structure of Dihydrofolate Reductase-thymidylate Synthase from Cryptosporidium Hominis Bound to 1843u89/nadph/dump
  152. 3fl9: Crystal Structure of B. Anthracis Dihydrofolate Reductase (dhfr) with Trimethoprim
  153. 3fl8: Crystal Structure of B. Anthracis Dihydrofolate Reductase (dhfr) with Rab1, a Tmp-dihydrophthalazine Derivative
  154. 3f91: Structural Data for Human Active Site Mutant Enzyme Complexes
  155. 3f8z: Human Dihydrofolate Reductase Structural Data with Active Site Mutant Enzyme Complexes
  156. 3f8y: Correlations of Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes
  157. 3f0x: Staphylococcus Aureus F98Y Mutant Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3-methoxy-5-(3, 5-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine
  158. 3f0v: Staphylococcus Aureus F98Y Mutant Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3-methoxy-5-(2, 6-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine
  159. 3f0u: Staphylococcus Aureus F98Y Mutant Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3-methoxy-5- Phenylphenyl)but-1-ynyl]-6-methylpyrimidine
  160. 3f0s: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3-methoxy-5-(3,5- Dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine
  161. 3f0q: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)but-1-ynyl]- 6-methylpyrimidine
  162. 3f0b: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-[3-(3-methoxy-5-phenylphenyl) But-1-ynyl]-6-methylpyrimidine
  163. 1tdr: Expression, Characterization, and Crystallographic Analysis of Telluromethionyl Dihydrofolate Reductase
  164. 3eig: Crystal Structure of a Methotrexate-resistant Mutant of Human Dihydrofolate Reductase
  165. 3e0b: Bacillus Anthracis Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1- Ynyl)-6-ethylpyrimidine (UCP120B)
  166. 3drc: Investigation of The Functional Role of Tryptophan-22 in Escherichia Coli Dihydrofolate Reductase by Site-directed Mutagenesis
  167. 1u70: Understanding The Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and LEU22ARG Variant Mouse and Human Dihydrofolate Reductase
  168. 1u71: Understanding The Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and LEU22ARG Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and Nadph
  169. 1u72: Understanding The Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and LEU22ARG Variant Mouse and Human Dihydrfolate Reductase Ternary Crystal Complexes with Methotrexate and Nadph
  170. 3dl6: Crystal Structure of The A287F/S290G Active Site Mutant of Ts-dhfr from Cryptosporidium Hominis
  171. 3dl5: Crystal Structure of The A287F Active Site Mutant of Ts- Dhfr from Cryptosporidium Hominis
  172. 3dga: Wild-type Plasmodium Falciparum Dihydrofolate Reductase- Thymidylate Synthase (pfdhfr-ts) Complexed with Rjf01302, Nadph, and Dump
  173. 3dg8: Quadruple Mutant (N51I+C59R+S108N+I164L) Plasmodium Falciparum Dihydrofolate Reductase-thymidylate Synthase (pfdhfr-ts) Complexed with Rjf670, Nadph, and Dump
  174. 3dfr: Crystal Structures of Escherichia Coli and Lactobacillus Casei Dihydrofolate Reductase Refined at 1.7 Angstroms Resolution. I. General Features and Binding of Methotrexate
  175. 3dau: Crystal Structure of The Ternary Mtx Nadph Complex of Escherichia Coli Dihydrofolate Reductase
  176. 3dat: Crystal Structure of The Ternary Mtx Nadph Complex of Bacillus Anthracis Dihydrofolate Reductase
  177. 3d84: Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with Nadph and a Ternary Complex with The Potent and Selective Inhibitor 2.4-diamino-6-(-2'- Hydroxydibenz[b,f]azepin-5-yl)methylpteridine
  178. 3d80: Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with Nadph and a Ternary Complex Wtih The Potent and Selective Inhibitor 2,4-diamino-6-(2'- Hydroxydibenz[b,f]azepin-5-yl)methylpteridine
  179. 3cse: Candida Glabrata Dihydrofolate Reductase Complexed with Nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1- Ynyl)-6-ethylpyrimidine (UCP120B)
  180. 3clb: Structure of Bifunctional Tcdhfr-ts in Complex with Tmq
  181. 3cl9: Structure of Bifunctional Tcdhfr-ts in Complex with Mtx
  182. 3cd2: Ligand Induced Conformational Changes in The Crystal Structures of Pneumocystis Carinii Dihydrofolate Reductase Complexes with Folate and Nadp+
  183. 1vdr: Dihydrofolate Reductase
  184. 1vie: Structure of Dihydrofolate Reductase
  185. 1vif: Structure of Dihydrofolate Reductase
  186. 1vj3: Structural Studies on Bio-active Compounds. Crystal Structure and Molecular Modeling Studies on The Pneumocystis Carinii Dihydrofolate Reductase Cofactor Complex with Tab, a Highly Selective Antifolate.
  187. 2zza: Moritella Profunda Dihydrofolate Reductase Complex with Nadp+ and Folate
  188. 1yho: Solution Structure of Human Dihydrofolate Reductase Complexed with Trimethoprim and Nadph, 25 Structures
  189. 2w9t: Staphylococcus Aureus S1:dhfr
  190. 2w9s: Staphylococcus Aureus S1:dhfr in Complex with Trimethoprim
  191. 2w9h: Wild-type Staphylococcus Aureus Dhfr in Complex with Trimethoprim
  192. 2w9g: Wild-type Staphylococcus Aureus Dhfr in Complex with Nadph and Trimethoprim
  193. 1zdr: Dhfr from Bacillus Stearothermophilus
  194. 2w3w: Mycobacterium Avium Dihydrofolate Reductase Complexed with Nadph and a Lipophilic Antifolate Selective for M. Avium Dhfr, 6-((2,5-diethoxyphenyl)aminomethyl)-2,4-diamino-5- Methylpyrido(2,3-d)pyrimidine (sri-8686)
  195. 2w3v: Mycobacterium Avium Dihydrofolate Reductase Complexed with Nadph and Trimethoprim
  196. 2w3m: Human Dihydrofolate Reductase Complexed with Nadph and Folate
  197. 2w3b: Human Dihydrofolate Reductase Complexed with Nadph and a Lipophilic Antifolate Selective for Mycobacterium Avium Dhfr, 6-((2,5-diethoxyphenyl)aminomethyl)-2,4-diamino-5- Methylpyrido(2,3-d)pyrimidine (sri-8686)
  198. 2w3a: Human Dihydrofolate Reductase Complexed with Nadph and Trimethoprim
  199. 2ano: Crystal Structure of E.coli Dihydrofolate Reductase in Complex with Nadph and The Inhibitor Ms-sh08-17
  200. 2anq: Crystal Structure of E.coli Dhfr in Complex with Nadph and The Inhibitor Compound 10a.
  201. 2rk2: Dhfr R-67 Complexed with Nadp
  202. 2rk1: Dhfr R67 Complexed with Nadp and Dihydrofolate
  203. 2rh2: High Resolution Dhfr R-67
  204. 2bl9: X-ray Crystal Structure of Plasmodium Vivax Dihydrofolate Reductase in Complex with Pyrimethamine and Its Derivative
  205. 2bla: Sp21 Double Mutant P. Vivax Dihydrofolate Reductase in Complex with Pyrimethamine
  206. 2blb: X-ray Crystal Structure of Plasmodium Vivax Dihydrofolate Reductase in Complex with Pyrimethamine and Its Derivative
  207. 2blc: Sp21 Double Mutant P. Vivax Dihydrofolate Reductase in Complex with Des-chloropyrimethamine
  208. 2c2s: Human Dihydrofolate Reductase Complexed with Nadph and 2,4- Diamino-5-(1-o-carboranylmethyl)-6-methylpyrimidine, a Novel Boron Containing, Nonclassical Antifolate
  209. 2c2t: Human Dihydrofolate Reductase Complexed with Nadph and 2,4- Diamino-5-((7,8-dicarbaundecaboran-7-yl)methyl)-6- Methylpyrimidine, a Novel Boron Containing, Nonclassical Antifolate
  210. 2qk8: Crystal Structure of The Anthrax Drug Target, Bacillus Anthracis Dihydrofolate Reductase
  211. 2cd2: Ligand Induced Conformational Changes in The Crystal Structures of Pneumocystis Carinii Dihydrofolate Reductase Complexes with Folate and Nadp+
  212. 2cig: Dihydrofolate Reductase from Mycobacterium Tuberculosis Inhibited by The Acyclic 4r Isomer of Inh-nadp a Derivative of The Prodrug Isoniazid.
  213. 2d0k: Methionine-free Mutant of Escherichia Coli Dihydrofolate Reductase
  214. 2p4t: Structure of The Q67H Mutant of R67 Dihydrofolate Reductase- Nadp+ Complex Reveals a Novel Cofactor Binding Mode
  215. 2dhf: Crystal Structures of Recombinant Human Dihydrofolate Reductase Complexed with Folate and 5-deazofolate
  216. 2oip: Crystal Structure of The S290G Active Site Mutant of Ts- Dhfr from Cryptosporidium Hominis
  217. 2drc: Investigation of The Functional Role of Tryptophan-22 in Escherichia Coli Dihydrofolate Reductase by Site-directed Mutagenesis
  218. 2fzh: New Insights into Dihydrofolate Reductase Interactions: Analysis of Pneumocystis Carinii and Mouse Dhfr Complexes with Nadph and Two Highly Potent Trimethoprim Derivatives
  219. 2fzi: New Insights into Dhfr Interactions: Analysis of Pneumocystis Carinii and Mouse Dhfr Complexes with Nadph and Two Highly Potent Trimethoprim Derivatives
  220. 2fzj: New Insights into Dhfr Interactions: Analysis of Pneumocystis Carinii and Mouse Dhfr Complexes with Nadph and Two Highly Potent Trimethoprim Derivatives
  221. 2gqv: High-resolution Structure of a Plasmid-encoded Dihydrofolate Reductase: Pentagonal Network of Water Molecules in The D2-symmetric Active Site
  222. 2h2q: Crystal Structure of Trypanosoma Cruzi Dihydrofolate Reductase-thymidylate Synthase
  223. 2hm9: Solution Structure of Dihydrofolate Reductase Complexed with Trimethoprim, 33 Structures
  224. 2hqp: Solution Structure of L.casei Dihydrofolate Reductase Complexed with Nadph, 32 Structures
  225. 2inq: Neutron Crystal Structure of Escherichia Coli Dihydrofolate Reductase Bound to The Anti-cancer Drug, Methotrexate
  226. 2ith: Nmr Structure of Haloferax Volcanii Dhfr
  227. 2jyb: Binary Hvdhfr1:folate Complex
  228. 3kfy: Dynamic Switching and Partial Occupancies of a Small Molecule Inhibitor Complex of Dhfr
  229. 3och: Chemically Self-assembled Antibody Nanorings (csans): Design and Characterization of an Anti-cd3 Igm Biomimetic
  230. 3l3r: Structural, Computational and Kinetic Data for Antifolate Interactions against Pneumocystis Jirovecii, Pneumocystis Carinii and Human Dihydrofolate Reductase and Their Active Site Mutants
  231. 3nxx: Preferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for The E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro-2,3-d]pyrimidines as Ternary Complexes with Nadph and Human Dihydrofolate Reductase
  232. 3nxy: Preferential Selection of Isomer Binding from Chiral Mixtures: Alernate Binding Modes Observed Fro The E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as Ternary Complexes with Nadph and Human Dihydrofolate Reductase
  233. 3nz6: Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and a Series of Five Potent 5-(omega-carboxy(alkyloxy) Pyrido[2,3-d]pyrimidine Derivatives
  234. 3nz9: Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and a Series of Five Potent 5-(omega-carboxy(alkyloxy) Pyrido[2,3-d]pyrimidine Derivatives
  235. 3nza: Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and a Series of Five Potent 5-(omega-carboxy(alkyloxy) Pyrido[2,3-d]pyrimidine Derivatives
  236. 3nzb: Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and a Series of Potent 5-(omega-carboxyl(alkyloxy) Pyrido[2,-d]pyrimidine Derivatives
  237. 3nzc: Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and a Series of Five Potent 5-(omega-carboxy(alkyloxy) Pyrido[2,3-d]pyridine Derivativea
  238. 3nzd: Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes with Nadph and a Series of Five 5-(omega-carboxy(alkyloxy(pyrido[2,3- D]pyrimidine Derivatives
  239. 3q1h: Crystal Structure of Dihydrofolate Reductase from Yersinia Pestis
  240. 2l28: Solution Structure of Lactobacillus Casei Dihydrofolate Reductase Apo- Form, 25 Conformers
  241. 3ql0: Crystal Structure of N23PP/S148A Mutant of E. Coli Dihydrofolate Reductase
  242. 3ql3: Re-refined Coordinates for Pdb Entry 1rx2
  243. 3ntz: Design, Synthesis, Biological Evaluation and X-ray Crystal Structures of Novel Classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors
  244. 3nu0: Design, Synthesis, Biological Evaluation and X-ray Crystal Structure of Novel Classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors
  245. 3qfx: Trypanosoma Brucei Dihydrofolate Reductase Pyrimethamine Complex
  246. 3qg2: Plasmodium Falciparum Dhfr-ts Qradruple Mutant (N51I+C59R+S108N+I164L, V1/s) Pyrimethamine Complex
  247. 3qgt: Crystal Structure of Wild-type Pfdhfr-ts Complexed with Nadph, Dump and Pyrimethamine
  248. 3rg9: Trypanosoma Brucei Dihydrofolate Reductase (tbdhfr) in Complex with Wr99210
  249. 3oaf: Structural and Kinetic Data for Antifolate Interactions against Pneumocystis Jirovecii, Pneumocystis Carinii and Human Dihydrofolate Reductase and Thier Active Site Mutants
  250. 3sqy: S. Aureus Dihydrofolate Reductase Complexed with Novel 7-aryl-2,4- Diaminoquinazolines
  251. 3sr5: S. Aureus Dihydrofolate Reductase Complexed with Novel 7-aryl-2,4- Diaminoquinazolines
  252. 3srq: S. Aureus Dihydrofolate Reductase Complexed with Novel 7-aryl-2,4- Diaminoquinazolines
  253. 3srr: S. Aureus Dihydrofolate Reductase Complexed with Novel 7-aryl-2,4- Diaminoquinazolines
  254. 3srs: S. Aureus Dihydrofolate Reductase Complexed with Novel 7-aryl-2,4- Diaminoquinazolines
  255. 3sru: S. Aureus Dihydrofolate Reductase Complexed with Novel 7-aryl-2,4- Diaminoquinazolines
  256. 3srw: S. Aureus Dihydrofolate Reductase Complexed with Novel 7-aryl-2,4- Diaminoquinazolines
  257. 3n0h: Hdhfr Double Mutant Q35S/N64F Trimethoprim Binary Complex
  258. 3s3v: Human Dihydrofolate Reductase Q35K/N64F Double Mutant Binary Complex with Trimethoprim
  259. 3s7a: Human Dihydrofolate Reductase Binary Complex with Pt684
  260. 3sfm: Novel Crystallization Conditions for Tandem Variant R67 Dhfr Yields Wild-type Crystal Structure
  261. 3tq8: Structure of The Dihydrofolate Reductase (fola) from Coxiella Burnetii in Complex with Trimethoprim
  262. 3tq9: Structure of The Dihydrofolate Reductase (fola) from Coxiella Burnetii in Complex with Methotrexate
  263. 3tqa: Structure of The Dihydrofolate Reductase (fola) from Coxiella Burnetii in Complex with Nadph
  264. 3tqb: Structure of The Dihydrofolate Reductase (fola) from Coxiella Burnetii in Complex with Folate
  265. 2lf1: Solution Structure of L. Casei Dihydrofolate Reductase Complexed with Nadph, 30 Structures
  266. 3qyl: Sensitivity of Receptor Internal Motions to Ligand Binding Affinity and Kinetic Off-rate
  267. 3qyo: Sensitivity of Receptor Internal Motions to Ligand Binding Affinity and Kinetic Off-rate
  268. 3r33: Evidence for Dynamic Motion in Proteins as a Mechanism for Ligand Dissociation
  269. 3sgy: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 6-ethyl-5-[(3s)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1- Yl]pyrimidine-2,4-diamine (ucp1006)
  270. 3sh2: Staphylococcus Aureus Dihydrofolate Reductase Complexed with Nadph and 6-ethyl-5-(3-(4-methoxybiphenyl-3-yl)prop-1-ynyl)pyrimidine-2,4- Diamine (UCP120J)
  271. 3td8: Structural Analysis of Pneumocystis Carinii Dihydrofolate Reductase Complex with Nadph and 2,4-diamino-5-methyl-6-[2'-(4-carboxy-1- Pentynyl)-5'-methoxybenzyl]pyrido[2,3-d]pyrimidine
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