EC 3.4.21.5 - thrombin

3D structures of EC 3.4.21.5 - thrombin in Protein Data Bank

updated: 9 February 2012, 15:47

1. 1a0h: The X-ray Crystal Structure of Ppack-meizothrombin Desf1: Kringle/thrombin and Carbohydrate/kringle/thrombin Interactions and Location of The Linker Chain
2. 1a2c: Structure of Thrombin Inhibited by Aeruginosin298-a from a Blue-green Alga
3. 1a3b: Complex of Human Alpha-thrombin with The Bifunctional Boronate Inhibitor Borolog1
4. 1a3e: Complex of Human Alpha-thrombin with The Bifunctional Boronate Inhibitor Borolog2
5. 1a46: Thrombin Complexed with Hirugen and a Beta-strand Mimetic Inhibitor
6. 1a4w: Crystal Structures of Thrombin with Thiazole-containing Inhibitors: Probes of The S1' Binding Site
7. 1a5g: Human Thrombin Complexed with Novel Synthetic Peptide Mimetic Inhibitor and Hirugen
8. 1a61: Thrombin Complexed with a Beta-mimetic Thiazole-containing Inhibitor
9. 1abi: Structure of The Hirulog 3-thrombin Complex and Nature of The S' Subsites of Substrates and Inhibitors
10. 1abj: Structure of The Hirulog 3-thrombin Complex and Nature of The S' Subsites of Substrates and Inhibitors
11. 1ad8: Complex of Thrombin with and Inhibitor Containing a Novel P1 Moiety
12. 1ae8: Human Alpha-thrombin Inhibition by Eoc-d-phe-pro-azalys-onp
13. 1afe: Human Alpha-thrombin Inhibition by Cbz-pro-azalys-onp
14. 1aht: Crystal Structure of Human Alpha-thrombin Complexed with Hirugen and P-amidinophenylpyruvate) at 1.6 Angstroms Resolution
15. 1ai8: Human Alpha-thrombin Ternary Complex with The Exosite Inhibitor Hirugen and Active Site Inhibitor PHCH2OCO-D-DPA- Pro-borompg
16. 1aix: Human Alpha-thrombin Ternary Complex with Exosite Inhibitor Hirugen and Active Site Inhibitor PHCH2OCO-D-DPA-PRO- Boroval
17. 1avg: Thrombin Inhibitor from Triatoma Pallidipennis
18. 1awf: Novel Covalent Thrombin Inhibitor from Plant Extract
19. 1awh: Novel Covalent Thrombin Inhibitor from Plant Extract
20. 1ay6: Thrombin Inhibitor from Theonalla, Cyclotheanamide-based Macrocyclic Tripeptide Motif
21. 1b5g: Human Thrombin Complexed with Novel Synthetic Peptide Mimetic Inhibitor and Hirugen
22. 1b7x: Structure of Human Alpha-thrombin Y225I Mutant Bound to D- Phe-pro-arg-chloromethylketone
23. 1ba8: Thrombin Inhibitor with a Rigid Tripeptidyl Aldehydes
24. 1bb0: Thrombin Inhibitors with Rigid Tripeptidyl Aldehydes
25. 1bbr: The Structure of Residues 7-16 of The a Alpha Chain of Human Fibrinogen Bound to Bovine Thrombin at 2.3 Angstroms Resolution
26. 1bcu: Alpha-thrombin Complexed with Hirugen and Proflavin
27. 1bhx: X-ray Structure of The Complex of Human Alpha Thrombin with The Inhibitor Sdz 229-357
28. 1bmm: Human Alpha-thrombin Complexed with [s-(r*,r*)]-4- [(aminoiminomethyl)amino]-n-[[1-[3-hydroxy-2-[(2- Naphthalenylsulfonyl)amino]-1-oxopropyl]-2-pyrrolidinyl] Methyl]butanamide (bms-186282)
29. 1bmn: Human Alpha-thrombin Complexed with [s-(r*,r*)]-1- (aminoiminomethyl)-n-[[1-[n-[(2-naphthalenylsulfonyl)-l- Seryl]-pyrrolidinyl]methyl]-3-piperidenecarboxamide (bms- 189090)
30. 1bth: Structure of Thrombin Complexed with Bovine Pancreatic Trypsin Inhibitor
31. 1c1u: Recruiting Zinc to Mediate Potent, Specific Inhibition of Serine Proteases
32. 1c1v: Recruiting Zinc to Mediate Potent, Specific Inhibition of Serine Proteases
33. 1c1w: Recruiting Zinc to Mediate Potent, Specific Inhibition of Serine Proteases
34. 1c4u: Selective Non Electrophilic Thrombin Inhibitors with Cyclohexyl Moieties.
35. 1c4v: Selective Non Electrophilic Thrombin Inhibitors with Cyclohexyl Moieties.
36. 1c4y: Selective Non-electrophilic Thrombin Inhibitors
37. 1c5l: Structural Basis for Selectivity of a Small Molecule, S1- Binding, Sub-micromolar Inhibitor of Urokinase Type Plasminogen Activator
38. 1c5n: Structural Basis for Selectivity of a Small Molecule, S1- Binding, Sub-micromolar Inhibitor of Urokinase Type Plasminogen Activator
39. 1c5o: Structural Basis for Selectivity of a Small Molecule, S1- Binding, Sub-micromolar Inhibitor of Urokinase Type Plasminogen Activator
40. 1ca8: Thrombin Inhibitors with Rigid Tripeptidyl Aldehydes
41. 1d3d: Crystal Structure of Human Alpha Thrombin in Complex with Benzothiophene Inhibitor 4
42. 1d3p: Crystal Structure of Human Aplha-thrombin in Complex with Benzo[b]thiophene Inhibitor 3
43. 1d3q: Crystal Structure of Human Alpha Thrombin in Complex with Benzo[b]thiophene Inhibitor 2
44. 1d3t: Crystal Structure of Human Alpha Thrombin in Complex with Benzo[b]thiophene Inhibitor 1
45. 1d4p: Crystal Structure of Human Alpha Thrombin in Complex with 5- Amidinoindole-4-benzylpiperidine Inhibitor
46. 1d6w: Structure of Thrombin Complexed with Selective Non- Electrophilic Inhibitors Having Cyclohexyl Moieties at P1
47. 1d9i: Structure of Thrombin Complexed with Selective Non- Electophilic Inhibitors Having Cyclohexyl Moieties at P1
48. 1de7: Interaction of Factor XIII Activation Peptide with Alpha- Thrombin: Crystal Structure of The Enzyme-substrate Complex
49. 1dit: Complex of a Divalent Inhibitor with Thrombin
50. 1doj: Crystal Structure of Human Alpha-thrombin*rwj-51438 Complex at 1.7 a
51. 1dwb: Crystallographic Analysis at 3.0-angstroms Resolution of The Binding to Human Thrombin of Four Active Site-directed Inhibitors
52. 1dwc: Crystallographic Analysis at 3.0-angstroms Resolution of The Binding to Human Thrombin of Four Active Site-directed Inhibitors
53. 1dwd: Crystallographic Analysis at 3.0-angstroms Resolution of The Binding to Human Thrombin of Four Active Site-directed Inhibitors
54. 1dwe: Crystallographic Analysis at 3.0-angstroms Resolution of The Binding to Human Thrombin of Four Active Site-directed Inhibitors
55. 1dx5: Crystal Structure of The Thrombin-thrombomodulin Complex
56. 1e0f: Crystal Structure of The Human Alpha-thrombin-haemadin Complex: an Exosite Ii-binding Inhibitor
57. 1eb1: Complex Structure of Human Thrombin with N-methyl-arginine Inhibitor
58. 1eoj: Design of P1' and P3' Residues of Trivalent Thrombin Inhibitors and Their Crystal Structures
59. 1eol: Design of P1' and P3' Residues of Trivalent Thrombin Inhibitors and Their Crystal Structures
60. 1etr: Refined 2.3 Angstroms X-ray Crystal Structure of Bovine Thrombin Complexes Formed with The Benzamidine and Arginine-based Thrombin Inhibitors Napap, 4-tapap and Mqpa: a Starting Point for Improving Antithrombotics
61. 1ets: Refined 2.3 Angstroms X-ray Crystal Structure of Bovine Thrombin Complexes Formed with The Benzamidine and Arginine-based Thrombin Inhibitors Napap, 4-tapap and Mqpa: a Starting Point for Improving Antithrombotics
62. 1ett: Refined 2.3 Angstroms X-ray Crystal Structure of Bovine Thrombin Complexes Formed with The Benzamidine and Arginine-based Thrombin Inhibitors Napap, 4-tapap and Mqpa: a Starting Point for Improving Antithrombotics
63. 1fpc: Active Site Mimetic Inhibition of Thrombin
64. 1fph: The Interaction of Thrombin with Fibrinogen: a Structural Basis for Its Specificity
65. 1g30: Thrombin Inhibitor Complex
66. 1g32: Thrombin Inhibitor Complex
67. 1g37: Crystal Structure of Human Alpha-thrombin Complexed with Bch-10556 and Exosite-directed Peptide
68. 1ghv: A Novel Serine Protease Inhibition Motif Involving a Multi- Centered Short Hydrogen Bonding Network at The Active Site
69. 1ghw: A Novel Serine Protease Inhibition Motif Involving a Multi- Centered Short Hydrogen Bonding Network at The Active Site
70. 1ghx: A Novel Serine Protease Inhibition Motif Involving a Multi- Centered Short Hydrogen Bonding Network at The Active Site
71. 1ghy: A Novel Serine Protease Inhibition Motif Involving a Multi- Centered Short Hydrogen Bonding Network at The Active Site
72. 1gj4: Selectivity at S1, H2O Displacement, Upa, Tpa, Ser190/ala190 Protease, Structure-based Drug Design
73. 1gj5: Selectivity at S1, H2O Displacement, Upa, Tpa, Ser190/ala190 Protease, Structure-based Drug Design
74. 1h8d: X-ray Structure of The Human Alpha-thrombin Complex with a Tripeptide Phosphonate Inhibitor.
75. 1h8i: X-ray Crystal Structure of Human Alpha-thrombin with a Tripeptide Phosphonate Inhibitor.
76. 1hag: The Isomorphous Structures of Prethrombin2, Hirugen-and Ppack-thrombin: Changes Accompanying Activation and Exosite Binding to Thrombin
77. 1hah: The Isomorphous Structures of Prethrombin2, Hirugen-and Ppack-thrombin: Changes Accompanying Activation and Exosite Binding to Thrombin
78. 1hai: The Isomorphous Structures of Prethrombin2, Hirugen-and Ppack-thrombin: Changes Accompanying Activation and Exosite Binding to Thrombin
79. 1hbt: Human Alpha-thrombin Complexed with a Peptidyl Pyridinium Methyl Ketone Containing Bivalent Inhibitor
80. 1hdt: Structure of a Retro-binding Peptide Inhibitor Complexed with Human Alpha-thrombin
81. 1hgt: Structure of The Hirugen and Hirulog 1 Complexes of Alpha- Thrombin
82. 1hrt: The Structure of a Complex of Bovine Alpha-thrombin and Recombinant Hirudin at 2.8 Angstroms Resolution
83. 1hut: The Structure of Alpha-thrombin Inhibited by a 15-mer Single-stranded Dna Aptamer
84. 1hxe: Serine Protease
85. 1hxf: Human Thrombin Complex with Hirudin Variant
86. 1id5: Crystal Structure of Bovine Thrombin Complex with Protease Inhibitor Ecotin
87. 1ihs: Crystal Structure of The Complex of Human Alpha-thrombin and Non-hydrolyzable Bifunctional Inhibitors, Hirutonin-2 and Hirutonin-6
88. 1iht: Crystal Structure of The Complex of Human Alpha-thrombin and Non-hydrolyzable Bifunctional Inhibitors, Hirutonin-2 and Hirutonin-6
89. 1jmo: Crystal Structure of The Heparin Cofactor II-S195A Thrombin Complex
90. 1jwt: Crystal Structure of Thrombin in Complex with a Novel Bicyclic Lactam Inhibitor
91. 1k21: Human Thrombin-inhibitor Complex
92. 1k22: Human Thrombin-inhibitor Complex
93. 8kme: Crystal Structure of Human Alpha-thrombin Inhibited with Sel2770.
94. 7kme: Crystal Structure of Human Alpha-thrombin Inhibited with Sel2711.
95. 5gds: Hirunorms Are True Hirudin Mimetics. The Crystal Structure of Human Alpha-thrombin:hirunorm V Complex
96. 4thn: The Crystal Structure of Alpha-thrombin-hirunorm IV Complex Reveals a Novel Specificity Site Recognition Mode.
97. 4htc: The Refined Structure of The Hirudin-thrombin Complex
98. 1kts: Thrombin Inhibitor Complex
99. 1ktt: Thrombin Inhibitor Complex
100. 1lhc: Human Alpha-thrombin Complexed with Ac-(d)phe-pro-boroarg-oh
101. 1lhd: Human Alpha-thrombin Complexed with Ac-(d)phe-pro-borolys-oh
102. 1lhe: Human Alpha-thrombin Complexed with Ac-(d)phe-pro-boro-n- Butyl-amidino-glycine-oh
103. 1lhf: Human Alpha-thrombin Complexed with Ac-(d)phe-pro-boro- Homolys-oh
104. 1lhg: Human Alpha-thrombin Complexed with Ac-(d)phe-pro- Boroornithine-oh
105. 3nxp: Crystal Structure of Human Prethrombin-1
106. 1mh0: Crystal Structure of The Anticoagulant Slow Form of Thrombin
107. 1mkw: The Co-crystal Structure of Unliganded Bovine Alpha- Thrombin and Prethrombin-2: Movement of The Yppw Segment and Active Site Residues upon Ligand Binding
108. 1mkx: The Co-crystal Structure of Unliganded Bovine Alpha- Thrombin and Prethrombin-2: Movement of The Yppw Segment and Active Site Residues upon Ligand Binding
109. 1mu6: Crystal Structure of Thrombin in Complex with L-378,622
110. 1mu8: Thrombin-hirugen_l-378,650
111. 1mue: Thrombin-hirugen-l405,426
112. 3lu9: Crystal Structure of Human Thrombin Mutant S195A in Complex with The Extracellular Fragment of Human Par1
113. 1nl1: Bovine Prothrombin Fragment 1 in Complex with Calcium Ion
114. 1nl2: Bovine Prothrombin Fragment 1 in Complex with Calcium and Lysophosphotidylserine
115. 1nm6: Thrombin in Complex with Selective Macrocyclic Inhibitor at 1.8a
116. 1no9: Design of Weakly Basic Thrombin Inhibitors Incorporating Novel P1 Binding Functions: Molecular and X-ray Crystallographic Studies.
117. 1nrn: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
118. 1nro: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
119. 1nrp: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
120. 1nrq: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
121. 1nrr: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
122. 1nrs: Crystallographic Structures of Thrombin Complexed with Thrombin Receptor Peptides: Existence of Expected and Novel Binding Modes
123. 1nt1: Thrombin in Complex with Selective Macrocyclic Inhibitor
124. 1nu7: Staphylocoagulase-thrombin Complex
125. 1nu9: Staphylocoagulase-prethrombin-2 Complex
126. 1ny2: Human Alpha Thrombin Inhibited by Rppgf and Hirugen
127. 1nzq: D-phe-pro-arg-type Thrombin Inhibitor
128. 1o0d: Human Thrombin Complexed with a D-phe-pro-arg-type Inhibitor and a C-terminal Hirudin Derived Exo-site Inhibitor
129. 1o2g: Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors
130. 1o5g: Dissecting and Designing Inhibitor Selectivity Determinants at The S1 Site Using an Artificial Ala190 Protease (ala190 Upa)
131. 1ook: Crystal Structure of The Complex of Platelet Receptor Gpib- Alpha and Human Alpha-thrombin
132. 3k65: Crystal Structure of Prethombin-2/fragment-2 Complex
133. 3jz2: Crystal Structure of Human Thrombin Mutant N143P in E* Form
134. 3jz1: Crystal Structure of Human Thrombin Mutant N143P in E:na+ Form
135. 1oyt: Complex of Recombinant Human Thrombin with a Designed Fluorinated Inhibitor
136. 1p8v: Crystal Structure of The Complex of Platelet Receptor Gpib- Alpha and Alpha-thrombin at 2.6a
137. 1ppb: The Refined 1.9 Angstroms Crystal Structure of Human Alpha- Thrombin: Interaction with D-phe-pro-arg Chloromethylketone and Significance of The Tyr-pro-pro-trp Insertion Segment
138. 1qbv: Crystal Structure of Thrombin Complexed with an Guanidine- Mimetic Inhibitor
139. 3htc: The Structure of a Complex of Recombinant Hirudin and Human Alpha-thrombin
140. 1qhr: Novel Covalent Active Site Thrombin Inhibitors
141. 1qj1: Novel Covalent Active Site Thrombin Inhibitors
142. 1qj6: Novel Covalent Active Site Thrombin Inhibitors
143. 1qj7: Novel Covalent Active Site Thrombin Inhibitors
144. 3hkj: Crystal Structure of Human Thrombin Mutant W215A/E217A in Complex with The Extracellular Fragment of Human Par1
145. 3hki: Crystal Structure of Murine Thrombin Mutant W215A/E217A in Complex with The Extracellular Fragment of Human Par1
146. 3hk6: Crystal Structure of Murine Thrombin Mutant W215A/E217A (two Molecules in The Asymmetric Unit)
147. 3hk3: Crystal Structure of Murine Thrombin Mutant W215A/E217A (one Molecule in The Asymmetric Unit)
148. 3hat: Active Site Mimetic Inhibition of Thrombin
149. 1rd3: 2.5a Structure of Anticoagulant Thrombin Variant E217K
150. 1riw: Thrombin in Complex with Natural Product Inhibitor Oscillarin
151. 3gis: Crystal Structure of Na-free Thrombin in Complex with Thrombomodulin
152. 3gic: Structure of Thrombin Mutant Delta(146-149e) in The Free Form
153. 1sb1: Novel Non-covalent Thrombin Inhibitors Incorporating P1 4,5, 6,7-tetrahydrobenzothiazole Arginine Side Chain Mimetics
154. 1sfq: Fast Form of Thrombin Mutant R(77a)a Bound to Ppack
155. 1sg8: Crystal Structure of The Procoagulant Fast Form of Thrombin
156. 1sgi: Crystal Structure of The Anticoagulant Slow Form of Thrombin
157. 1shh: Slow Form of Thrombin Bound with Ppack
158. 1sl3: Crystal Structue of Thrombin in Complex with a Potent P1 Heterocycle-aryl Based Inhibitor
159. 1sr5: Antithrombin-anhydrothrombin-heparin Ternary Complex Structure
160. 3f68: Thrombin Inhibition
161. 1t4u: Crystal Structure Analysis of a Novel Oxyguanidine Bound to Thrombin
162. 1t4v: Crystal Structure Analysis of a Novel Oxyguanidine Bound to Thrombin
163. 3eq0: Thrombin Inhibitor
164. 1ta2: Crystal Structure of Thrombin in Complex with Compound 1
165. 1ta6: Crystal Structure of Thrombin in Complex with Compound 14b
166. 1tb6: 2.5a Crystal Structure of The Antithrombin-thrombin-heparin Ternary Complex
167. 1tbq: Crystal Structure of Insect Derived Double Domain Kazal Inhibitor Rhodniin in Complex with Thrombin
168. 1tbr: Crystal Structure of Insect Derived Double Domain Kazal Inhibitor Rhodniin in Complex with Thrombin
169. 1tbz: Human Thrombin with Active Site N-methyl-d Phenylalanyl-n- [5-(aminoiminomethyl)amino]-1-{{benzothiazolyl)carbonyl] Butyl]-l-prolinamide Trifluroacetate and Exosite-hirugen
170. 1thp: Structure of Human Alpha-thrombin Y225P Mutant Bound to D- Phe-pro-arg-chloromethylketone
171. 1thr: Structures of Thrombin Complexes with a Designed and a Natural Exosite Inhibitor
172. 1ths: Structures of Thrombin Complexes with a Designed and a Natural Exosite Inhibitor
173. 3egk: Knoble Inhibitor
174. 3ee0: Crystal Structure of The W215A/E217A Mutant of Human Thrombin (space Group P2(1)2(1)2(1))
175. 3edx: Crystal Structure of The W215A/E217A Mutant of Murine Thrombin
176. 1tmb: Molecular Basis for The Inhibition of Human Alpha-thrombin by The Macrocyclic Peptide Cyclotheonamide a
177. 1tmt: Changes in Interactions in Complexes of Hirudin Derivatives and Human Alpha-thrombin due to Different Crystal Forms
178. 1tmu: Changes in Interactions in Complexes of Hirudin Derivatives and Human Alpha-thrombin due to Different Crystal Forms
179. 1toc: Structure of Serine Proteinase
180. 3e6p: Crystal Structure of Human Meizothrombin Desf1
181. 1tom: Alpha-thrombin Complexed with Hirugen
182. 1tq0: Crystal Structure of The Potent Anticoagulant Thrombin Mutant W215A/E217A in Free Form
183. 1tq7: Crystal Structure of The Anticoagulant Thrombin Mutant W215A/E217A Bound to Ppack
184. 1twx: Crystal Structure of The Thrombin Mutant D221A/D222K
185. 3dux: Understanding Thrombin Inhibition
186. 3dt0: Understanding Thrombin Inhibition
187. 3dhk: Bisphenylic Thrombin Inhibitors
188. 1ucy: Thrombin Complexed with Fibrinopeptide a Alpha (residues 7- 19). Three Complexes, One with Epsilon-thrombin and Two with Alpha-thrombin
189. 3dd2: Crystal Structure of an Rna Aptamer Bound to Human Thrombin
190. 3da9: Crystal Structure of Thrombin in Complex with Inhibitor
191. 3d49: Thrombin Inhibition
192. 1uma: Alpha-thrombin (hirugen) Complexed with Na-(n,n- Dimethylcarbamoyl)-alpha-azalysine
193. 1uvs: Bovine Thrombin--bm51.1011 Complex
194. 1uvt: Bovine Thrombin--bm14.1248 Complex
195. 1uvu: Bovine Thrombin--bm12.1700 Complex
196. 1vit: Thrombin:hirudin 51-65 Complex
197. 3c27: Cyanofluorophenylacetamides as Orally Efficacious Thrombin Inhibitors
198. 3c1k: Crystal Structure of Thrombin in Complex with Inhibitor 15
199. 3bv9: Structure of Thrombin Bound to The Inhibitor Fm19
200. 1vzq: Complex of Thrombin with Designed Inhibitor 7165
201. 3biv: Human Thrombin-in Complex with Ub-thr11
202. 3biu: Human Thrombin-in Complex with Ub-thr10
203. 3bf6: Thrombin:suramin Complex
204. 3bei: Crystal Structure of The Slow Form of Thrombin in a Self_inhibited Conformation
205. 3bef: Crystal Structure of Thrombin Bound to The Extracellular Fragment of Par1
206. 1w7g: Alpha-thrombin Complex with Sulfated Hirudin (residues 54- 65) and L-arginine Template Inhibitor Cs107
207. 3b9f: 1.6 a Structure of The Pci-thrombin-heparin Complex
208. 1way: Active Site Thrombin Inhibitors
209. 1wbg: Active Site Thrombin Inhibitors
210. 2zo3: Bisphenylic Thrombin Inhibitors
211. 2znk: Thrombin Inhibition
212. 2ziq: Thrombin Inhibition
213. 2zi2: Thrombin Inhibition
214. 2zhw: Exploring Thrombin S3 Pocket
215. 2zhq: Thrombin Inhibition
216. 2zhf: Exploring Thrombin S3 Pocket
217. 2zhe: Exploring Thrombin S3 Pocket
218. 2zgx: Thrombin Inhibition
219. 2zgb: Thrombin Inhibition
220. 2zg0: Exploring Thrombin S3 Pocket
221. 2zfr: Exploring Thrombin S3 Pocket
222. 2zfq: Exploring Thrombin S3 Pocket
223. 2zfp: Thrombin Inibition
224. 2zff: Exploring Thrombin S1-pocket
225. 2zf0: Exploring Thrombin S1 Pocket
226. 2zdv: Exploring Thrombin S1 Pocket
227. 2zda: Exploring Thrombin S1 Pocket
228. 2zc9: Thrombin in Complex with Inhibitor
229. 1xm1: Nonbasic Thrombin Inhibitor Complex
230. 1xmn: Crystal Structure of Thrombin Bound to Heparin
231. 1ycp: The Crystal Structure of Fibrinogen-aa Peptide 1-23 (F8Y) Bound to Bovine Thrombin Explains Why The Mutation of Phe- 8 to Tyrosine Strongly Inhibits Normal Cleavage at Arginine-16
232. 1ype: Thrombin Inhibitor Complex
233. 1ypg: Thrombin Inhibitor Complex
234. 1ypj: Thrombin Inhibitor Complex
235. 1ypk: Thrombin Inhibitor Complex
236. 1ypl: X-ray Crystal Structure of Thrombin Inhibited by Synthetic Cyanopeptide Analogue Ra-1008
237. 1ypm: X-ray Crystal Structure of Thrombin Inhibited by Synthetic Cyanopeptide Analogue Ra-1014
238. 1z71: Thrombin and P2 Pyridine N-oxide Inhibitor Complex Structure
239. 1z8i: Crystal Structure of The Thrombin Mutant G193A Bound to Ppack
240. 1z8j: Crystal Structure of The Thrombin Mutant G193P Bound to Ppack
241. 1zgi: Thrombin in Complex with an Oxazolopyridine Inhibitor 21
242. 1zgv: Thrombin in Complex with an Oxazolopyridine Inhibitor 2
243. 1zrb: Thrombin in Complex with an Azafluorenyl Inhibitor 23b
244. 2a0q: Structure of Thrombin in 400 Mm Potassium Chloride
245. 2a1d: Staphylocoagulase Bound to Bovine Thrombin
246. 2a2x: Orally Active Thrombin Inhibitors in Complex with Thrombin Inh12
247. 2a45: Crystal Structure of The Complex between Thrombin and The Central "e" Region of Fibrin
248. 2afq: 1.9 Angstrom Crytal Structure of Wild-type Human Thrombin in The Sodium Free State
249. 2v3o: Thrombin with 3-cycle with F
250. 2v3h: Thrombin with 3-cycle No F
251. 2ank: Orally Active Thrombin Inhibitors in Complex with Thrombin and an Exosite Decapeptide
252. 2anm: Ternary Complex of an Orally Active Thrombin Inhibitor with Human Thrombin and a C-terminal Hirudin Derived Exo-sit Inhibitor
253. 2uuk: Thrombin-hirugen-gw420128 Ternary Complex at 1.39a Resolution
254. 2uuj: Thrombin-hirugen-gw473178 Ternary Complex at 1.32a Resolution
255. 2uuf: Thrombin-hirugen Binary Complex at 1.26a Resolution
256. 2thf: Structure of Human Alpha-thrombin Y225F Mutant Bound to D- Phe-pro-arg-chloromethylketone
257. 2spt: Differences in The Metal Ion Structure between Sr-and Ca- Prothrombin Fragment 1
258. 2b5t: 2.1 Angstrom Structure of a Nonproductive Complex between Antithrombin, Synthetic Heparin Mimetic Sr123781 and Two S195A Thrombin Molecules
259. 2bdy: Thrombin in Complex with Inhibitor
260. 2bvr: Human Thrombin Complexed with Fragment-based Small Molecules Occupying The S1 Pocket
261. 2bvs: Human Thrombin Complexed with Fragment-based Small Molecules Occupying The S1 Pocket
262. 2bvx: Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-p2-linker
263. 2r2m: 2-(2-chloro-6-fluorophenyl)acetamides as Potent Thrombin Inhibitors
264. 2bxt: Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-p2-linker
265. 2bxu: Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-p2-linker
266. 2c8w: Thrombin Inhibitors
267. 2c8x: Thrombin Inhibitors
268. 2c8y: Thrombin Inhibitors
269. 2c8z: Thrombin Inhibitors
270. 2c90: Thrombin Inhibitors
271. 2c93: Thrombin Inhibitors
272. 2cf8: Complex of Recombinant Human Thrombin with a Inhibitor
273. 2cf9: Complex of Recombinant Human Thrombin with a Inhibitor
274. 2cn0: Complex of Recombinant Human Thrombin with a Designed Inhibitor
275. 2pgq: Human Thrombin Mutant C191A-C220A in Complex with The Inhibitor Ppack
276. 2pgb: Inhibitor-free Human Thrombin Mutant C191A-C220A
277. 2ody: Thrombin-bound Boophilin Displays a Functional and Accessible Reactive-site Loop
278. 2feq: Orally Active Thrombin Inhibitors
279. 2fes: Orally Active Thrombin Inhibitors
280. 2gde: Thrombin in Complex with Inhibitor
281. 2gp9: Crystal Structure of The Slow Form of Thrombin in a Self- Inhibited Conformation
282. 2h9t: Crystal Structure of Human Alpha-thrombin in Complex with Suramin
283. 2hgt: Structure of The Hirugen and Hirulog 1 Complexes of Alpha- Thrombin
284. 2hpp: Structures of The Noncovalent Complexes of Human and Bovine Prothrombin Fragment 2 with Human Ppack-thrombin
285. 2hpq: Structures of The Noncovalent Complexes of Human and Bovine Prothrombin Fragment 2 with Human Ppack-thrombin
286. 2hwl: Crystal Structure of Thrombin in Complex with Fibrinogen Gamma' Peptide
287. 2jh0: Human Thrombin Hirugen Inhibitor Complex.
288. 2jh5: Human Thrombin Hirugen Inhibitor Complex.
289. 2jh6: Human Thrombin Hirugen Inhibitor Complex.
290. 3r3g: Structure of Human Thrombin with Residues 145-150 of Murine Thrombin.
291. 3p6z: Structural Basis of Thrombin Mediated Factor V Activation: Essential Role of The Hirudin-like Sequence Glu666-glu672 for Processing at The Heavy Chain-b Domain Junction
292. 3pma: 2.2 Angstrom Crystal Structure of The Complex between Bovine Thrombin and Sucrose Octasulfate
293. 3pmb: 2.9 Angstrom Crystal Structure of Bovine Thrombin in Tetragonal Spacegroup
294. 3pmh: Mechanism of Sulfotyrosine-mediated Glycoprotein Ib Interaction with Two Distinct Alpha-thrombin Sites
295. 3qdz: Crystal Structure of The Human Thrombin Mutant D102N in Complex with The Extracellular Fragment of Human Par4.
296. 3qgn: The Allosteric E*-e Equilibrium Is a Key Property of The Trypsin Fold
297. 3s7h: Structure of Thrombin Mutant Y225P in The E* Form
298. 3s7k: Structure of Thrombin Mutant Y225P in The E Form
299. 3ldx: Discovery and Clinical Evaluation of Rwj-671818, a Thrombin Inhibitor with an Oxyguanidine P1 Motif
300. 3p70: Structural Basis of Thrombin-mediated Factor V Activation: Essential Role of The Hirudin-like Sequence Glu666-glu672 for Processing at The Heavy Chain-b Domain Junction
301. 3tu7: Human Alpha-thrombin Complexed with N-(methylsulfonyl)-d-phenylalanyl- N-((1-carbamimidoyl-4-piperidinyl)methyl)-l-prolinamide (bms-189664)
302. 3qlp: X-ray Structure of The Complex between Human Alpha Thrombin and a Modified Thrombin Binding Aptamer (mtba)
303. 3p17: Thrombin Inhibition by Pyridin Derivatives
304. 3b23: Crystal Structure of Thrombin-variegin Complex: Insights of a Novel Mechanism of Inhibition and Design of Tunable Thrombin Inhibitors
305. 3po1: Thrombin in Complex with Benzothiazole Guanidine
306. 3sqe: Crystal Structure of Prethrombin-2 Mutant S195A in The Alternative Form
307. 3sqh: Crystal Structure of Prethrombin-2 Mutant S195A in The The Open Form