EC 3.4.23.16 - HIV- 1 retropepsin

3D structures of EC 3.4.23.16 - HIV-1 retropepsin in Protein Data Bank

updated: 9 February 2012, 15:47

1. 1a30: Hiv-1 Protease Complexed with a Tripeptide Inhibitor
2. 1a8g: Hiv-1 Protease in Complex with Sdz283-910
3. 1a8k: Crystallographic Analysis of Human Immunodeficiency Virus 1 Protease with an Analog of The Conserved Ca-p2 Substrate: Interactions with Frequently Occurring Glutamic Acid Residue at P2' Position of Substrates
4. 1a94: Structural Basis for Specificity of Retroviral Proteases
5. 1aid: Structure of a Non-peptide Inhibitor Complexed with Hiv-1 Protease: Developing a Cycle of Structure-based Drug Design
6. 1ajv: Hiv-1 Protease in Complex with The Cyclic Sulfamide Inhibitor Aha006
7. 1ajx: Hiv-1 Protease in Complex with The Cyclic Urea Inhibitor Aha001
8. 1axa: Active-site Mobility in Human Immunodeficiency Virus Type 1 Protease as Demonstrated by Crystal Structure of A28S Mutant
9. 1az5: Unliganded Siv Protease Structure in an "open" Conformation
10. 1b11: Structure of Feline Immunodeficiency Virus Protease Complexed with Tl-3-093
11. 1b6j: Hiv-1 Protease Complexed with Macrocyclic Peptidomimetic Inhibitor 1
12. 1b6k: Hiv-1 Protease Complexed with Macrocyclic Peptidomimetic Inhibitor 5
13. 1b6l: Hiv-1 Protease Complexed with Macrocyclic Peptidomimetic Inhibitor 4
14. 1b6m: Hiv-1 Protease Complexed with Macrocyclic Peptidomimetic Inhibitor 6
15. 1b6p: Hiv-1 Protease Complexed with Macrocyclic Peptidomimetic Inhibitor 7
16. 1bdl: Hiv-1 (2:31-37) Protease Complexed with Inhibitor Sb203386
17. 1bdq: Hiv-1 (2:31-37, 47, 82) Protease Complexed with Inhibitor Sb203386
18. 1bdr: Hiv-1 (2: 31, 33-37) Protease Complexed with Inhibitor Sb203386
19. 1bv7: Counteracting Hiv-1 Protease Drug Resistance: Structural Analysis of Mutant Proteases Complexed with Xv638 and Sd146, Cyclic Urea Amides with Broad Specificities
20. 1bv9: Hiv-1 Protease (I84V) Complexed with Xv638 of Dupont Pharmaceuticals
21. 1bve: Hiv-1 Protease-dmp323 Complex in Solution, Nmr, 28 Structures
22. 1bvg: Hiv-1 Protease-dmp323 Complex in Solution, Nmr Minimized Average Structure
23. 1bwa: Hiv-1 Protease (V82F/I84V) Double Mutant Complexed with Xv638 of Dupont Pharmaceuticals
24. 1bwb: Hiv-1 Protease (V82F/I84V) Double Mutant Complexed with Sd146 of Dupont Pharmaceuticals
25. 1d4h: Hiv-1 Protease in Complex with The Inhibitor Bea435
26. 1d4i: Hiv-1 Protease in Complex with The Inhibitor Bea425
27. 1d4j: Hiv-1 Protease in Complex with The Inhibitor Msl370
28. 1d4k: Hiv-1 Protease Complexed with a Macrocyclic Peptidomimetic Inhibitor
29. 1d4l: Hiv-1 Protease Complexed with a Macrocyclic Peptidomimetic Inhibitor
30. 1d4s: Hiv-1 Protease V82F/I84V Double Mutant/tipranavir Complex
31. 1d4y: Hiv-1 Protease Triple Mutant/tipranavir Complex
32. 1daz: Structural and Kinetic Analysis of Drug Resistant Mutants of Hiv-1 Protease
33. 1dmp: Structure of Hiv-1 Protease Complex
34. 1dw6: Structural and Kinetic Analysis of Drug Resistant Mutants of Hiv-1 Protease
35. 1ebk: Structural and Kinetic Analysis of Drug Resistant Mutants of Hiv-1 Protease
36. 1ebw: Hiv-1 Protease in Complex with The Inhibitor Bea322
37. 1eby: Hiv-1 Protease in Complex with The Inhibitor Bea369
38. 1ebz: Hiv-1 Protease in Complex with The Inhibitor Bea388
39. 1ec0: Hiv-1 Protease in Complex with The Inhibitor Bea403
40. 1ec1: Hiv-1 Protease in Complex with The Inhibitor Bea409
41. 1ec2: Hiv-1 Protease in Complex with The Inhibitor Bea428
42. 1ec3: Hiv-1 Protease in Complex with The Inhibitor Msa367
43. 1f7a: How Does a Symmetric Dimer Recognize an Asymmetric Substrate? a Substrate Complex of Hiv-1 Protease.
44. 1fej: Structural Implications of Drug Resistant Mutants of Hiv-1 Protease: High Resolution Crystal Structures of The Mutant Protease/substrate Analog Complexes
45. 1ff0: Structural Implications of Drug Resistant Mutants of Hiv-1 Protease: High Resolution Crystal Structures of The Mutant Protease/substrate Analog Complexes.
46. 1fff: Structural Implications of Drug Resistant Mutants of Hiv-1 Protease : High Resolution Crystal Structures of The Mutant Protease/substrate Analog Complexes.
47. 1ffi: Structural Implications of Drug Resistant Mutants of Hiv-1 Protease: High Resolution Crystal Structures of The Mutant Protease/substrate Analog Complexes
48. 1fg6: Structural Implications of Drug Resistant Mutants of Hiv-1 Protease: High Resolution Crystal Structures of The Mutant Protease/substrate Analog Complexes
49. 1fg8: Structural Implications of Drug Resistant Mutants of Hiv-1 Protease: High Resolution Crystal Structures of The Mutant Protease/substrate Analog Complexes
50. 1fgc: Structural Implications of Drug Resistant Mutants of Hiv-1 Protease: High Resolution Crystal Structures of The Mutant Protease/substrate Analog Complexes
51. 1fiv: Structure of an Inhibitor Complex of Proteinase from Feline Immunodeficiency Virus
52. 1fmb: Eiav Protease Complexed with The Inhibitor Hby-793
53. 1fqx: Crystal Structure of The Complex of Hiv-1 Protease with a Peptidomimetic Inhibitor
54. 1g2k: Hiv-1 Protease with Cyclic Sulfamide Inhibitor, Aha047
55. 1g35: Crystal Structure of Hiv-1 Protease in Complex with Inhibitor, Aha024
56. 1g6l: 1.9a Crystal Structure of Tethered Hiv-1 Protease
57. 1hpo: Hiv-1 Protease Triple Mutant/u103265 Complex
58. 1hvh: Nonpeptide Cyclic Cyanoguanidines as Hiv Protease Inhibitors
59. 1hwr: Molecular Recognition of Cyclic Urea Hiv Protease Inhibitors
60. 1hxb: Hiv-1 Proteinase Complexed with Ro 31-8959
61. 1hxw: Hiv-1 Protease Dimer Complexed with A-84538
62. 1iiq: Crystal Structure of Hiv-1 Protease Complexed with a Hydroxyethylamine Peptidomimetic Inhibitor
63. 1izh: Inhibitor of Hiv Protease with Unusual Binding Mode Potently Inhibiting Multi-resistant Protease Mutants
64. 1izi: Inhibitor of Hiv Protease with Unusual Binding Mode Potently Inhibiting Multi-resistant Protease Mutants
65. 1jld: Potent Hiv Protease Inhibitors Containing a Novel (hydroxyethyl)amide Isostere
66. 1k1t: Combining Mutations in Hiv-1 Protease to Understand Mechanisms of Resistance
67. 1k1u: Combining Mutations in Hiv-1 Protease to Understand Mechanisms of Resistance
68. 1k2b: Combining Mutations in Hiv-1 Protease to Understand Mechanisms of Resistance
69. 1k2c: Combining Mutations in Hiv-1 Protease to Understand Mechanisms of Resistance
70. 1k6c: Lack of Synergy for Inhibitors Targeting a Multi-drug Resistant Hiv-1 Protease
71. 1k6p: Lack of Synergy for Inhibitors Targeting a Multi-drug Resistant Hiv-1 Protease
72. 1k6t: Lack of Synergy for Inhibitors Targeting a Multi-drug Resistant Hiv-1 Protease
73. 1k6v: Lack of Synergy for Inhibitors Targeting a Multi-drug Resistant Hiv-1 Protease
74. 7upj: Hiv-1 Protease/u101935 Complex
75. 6upj: Hiv-2 Protease/u99294 Complex
76. 6fiv: Structural Studies of Hiv and Fiv Proteases Complexed with an Efficient Inhibitor of Fiv Pr
77. 5upj: Hiv-2 Protease/u99283 Complex
78. 5fiv: Structural Studies of Hiv and Fiv Proteases Complexed with an Efficient Inhibitor of Fiv Pr
79. 4upj: Human Immunodeficiency Virus Type 2 Protease Mutant with Lys 57 Replaced by Leu (K57L) Complex with U097410 [4- Hydroxy-3-[1-[3-[[[[(tert-butyloxycarbonyl) Aminomethyl]carbonyl]amino]phenyl]propyl]coumarin
80. 4fiv: Fiv Protease Complexed with an Inhibitor Lp-130
81. 3upj: Human Immunodeficiency Virus Type 2 Protease Mutant with Lys 57 Replaced by Leu (K57L) Complex with U096333 [4- Hydroxy-3-[1-(phenyl)propyl]-7-methoxycoumarin]
82. 3tlh: Structural Studies of Hiv and Fiv Proteases Complexed Withan Efficient Inhibitor of Fiv Pr
83. 1kj4: Substrate Shape Determines Specificity of Recognition Recognition for Hiv-1 Protease: Analysis of Crystal Structures of Six Substrate Complexes
84. 1kj7: Substrate Shape Determines Specificity of Recognition Recognition for Hiv-1 Protease: Analysis of Crystal Structures of Six Substrate Complexes
85. 1kjf: Substrate Shape Determines Specificity of Recognition Recognition for Hiv-1 Protease: Analysis of Crystal Structures of Six Substrate Complexes
86. 1kjg: Substrate Shape Determines Specificity of Recognition Recognition for Hiv-1 Protease: Analysis of Crystal Structures of Six Substrate Complexes
87. 1kjh: Substrate Shape Determines Specificity of Recognition Recognition for Hiv-1 Protease: Analysis of Crystal Structures of Six Substrate Complexes
88. 3oxc: Wild Type Hiv-1 Protease with Antiviral Drug Saquinavir
89. 1kzk: Je-2147-hiv Protease Complex
90. 3ok9: Crystal Structure of Wild-type Hiv-1 Protease with New Oxatricyclic Designed Inhibitor Grl-0519a
91. 3nuo: Crystal Structure of Hiv-1 Protease Mutant L90M with Antiviral Drug Amprenavir
92. 3nuj: Crystal Structure of Hiv-1 Protease Mutant I54V with Antiviral Drug Amprenavir
93. 3nu9: Crystal Structure of Hiv-1 Protease Mutant I84V with Antiviral Drug Amprenavir
94. 3nu6: Crystal Structure of Hiv-1 Protease Mutant I54M with Antiviral Drug Amprenavir
95. 3nu5: Crystal Structure of Hiv-1 Protease Mutant I50V with Antiviral Drug Amprenavir
96. 3nu4: Crystal Structure of Hiv-1 Protease Mutant V32I with Antiviral Drug Amprenavir
97. 3nu3: Wild Type Hiv-1 Protease with Antiviral Drug Amprenavir
98. 1lv1: Crystal Structure Analysis of The Non-active Site Mutant of Tethered Hiv-1 Protease to 2.1a Resolution
99. 1lzq: Crystal Structure of The Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with an Ethylenamine Peptidomimetic Inhibitor BOC-PHE-PSI[CH2CH2NH]-PHE-GLU-PHE-NH2
100. 1m0b: Hiv-1 Protease in Complex with an Ethyleneamine Inhibitor
101. 3n3i: Crystal Structure of G48V/C95F Tethered Hiv-1 Protease/saquinavir Complex
102. 1mer: Hiv-1 Mutant (I84V) Protease Complexed with Dmp450
103. 1mes: Hiv-1 Mutant (I84V) Protease Complexed with Dmp323
104. 1met: Hiv-1 Mutant (V82F) Protease Complexed with Dmp323
105. 1meu: Hiv-1 Mutant (V82F, I84V) Protease Complexed with Dmp323
106. 3mxe: Crystal Structure of Hiv-1 Protease Inhibitor, Kc32 Complexed with Wild-type Protease
107. 3mxd: Crystal Structure of Hiv-1 Protease Inhibitor Kc53 in Complex with Wild-type Protease
108. 1mrw: Structure of Hiv Protease (mutant Q7K L33I L63I) Complexed with Kni-577
109. 1mrx: Structure of Hiv Protease (mutant Q7K L33I L63I V82F I84V ) Complexed with Kni-577
110. 1msm: The Hiv Protease (mutant Q7K L33I L63I) Complexed with Kni- 764 (an Inhibitor)
111. 1msn: The Hiv Protease (mutant Q7K L33I L63I V82F I84V) Complexed with Kni-764 (an Inhibitor)
112. 1mt7: Viability of a Drug-resistant Hiv-1 Protease Mutant: Structural Insights for Better Antiviral Therapy
113. 1mt8: Viability of a Drug-resistant Hiv-1 Protease Mutant: Structural Insights for Better Antiviral Therapy
114. 1mt9: Viability of a Drug-resistant Hiv-1 Protease Mutant: Structural Insights for Better Antiviral Therapy
115. 1mtb: Viability of a Drug-resistant Hiv-1 Protease Mutant: Structural Insights for Better Antiviral Therapy
116. 1mtr: Hiv-1 Protease Complexed with a Cyclic Phe-ile-val Peptidomimetic Inhibitor
117. 1mui: Crystal Structure of Hiv-1 Protease Complexed with Lopinavir.
118. 1n49: Viability of a Drug-resistant Hiv-1 Protease Variant: Structural Insights for Better Anti-viral Therapy
119. 3lzv: Structure of Nelfinavir-resistant Hiv-1 Protease (D30N/N88D) in Complex with Darunavir.
120. 3lzu: Crystal Structure of a Nelfinavir Resistant Hiv-1 Crf01_ae Protease Variant (N88S) in Complex with The Protease Inhibitor Darunavir.
121. 3lzs: Crystal Structure of Hiv-1 Crf01_ae Protease in Complex with Darunavir
122. 1nh0: 1.03 a Structure of Hiv-1 Protease: Inhibitor Binding inside and outside The Active Site
123. 1npa: Crystal Structure of Hiv-1 Protease-hup
124. 1npv: Crystal Structure of Hiv-1 Protease Complexed with Ldc271
125. 1npw: Crystal Structure of Hiv Protease Complexed with Lgz479
126. 3kt2: Crystal Structure of N88D Mutant Hiv-1 Protease
127. 1odw: Native Hiv-1 Proteinase
128. 1odx: Hiv-1 Proteinase Mutant A71T, V82A
129. 1ody: Hiv-1 Protease Complexed with an Inhibitor Lp-130
130. 3kfs: Hiv Protease (pr) Dimer with Inhibitor Tl-3 Bound and Fragment 2f4 in The Outside/top of Flap
131. 3kfr: Hiv Protease (pr) Dimer with Inhibitor Tl-3 Bound and Fragment 1f1 in The Outside/top of Flap
132. 3kfp: Hiv Protease (pr) with Inhibitor Tl-3 Bound, and Dmsos in Exo Site
133. 3kfn: Hiv Protease (pr) with Inhibitor Tl-3 and Fragment Hit 4d9 by Soaking
134. 3kf1: Hiv Protease (pr) Dimer without Inhibitor; Acetate in Exo Site
135. 3kf0: Hiv Protease with Fragment 4d9 Bound
136. 3kdd: Crystal Structure of Hiv-1 Protease (Q7K, L33I, L63I) in Complex with Kni-10265
137. 3kdc: Crystal Structure of Hiv-1 Protease (Q7K, L33I, L63I) in Complex with Kni-10074
138. 3kdb: Crystal Structure of Hiv-1 Protease (Q7K, L33I, L63I) in Complex with Kni-10006
139. 3k4v: New Crystal Form of Hiv-1 Protease/saquinavir Structure Reveals Carbamylation of N-terminal Proline
140. 3jw2: Hiv-1 Protease Mutant G86S with Darunavir
141. 3jvy: Hiv-1 Protease Mutant G86A with Darunavir
142. 3jvw: Hiv-1 Protease Mutant G86A with Symmetric Inhibitor Dmp323
143. 1pro: Hiv-1 Protease Dimer Complexed with A-98881
144. 3i8w: Crystal Structure of a Metallacarborane Inhibitor Bound to Hiv Protease
145. 3i6o: Crystal Structure of Wild Type Hiv-1 Protease with Macrocyclic Inhibitor Grl-0216a
146. 1q94: Structures of Hla-a*1101 in Complex with Immunodominant Nonamer and Decamer Hiv-1 Epitopes Clearly Reveal The Presence of a Middle Anchor Residue
147. 1q9p: Solution Structure of The Mature Hiv-1 Protease Monomer
148. 1qbr: Hiv-1 Protease Inhibitors Wiih Low Nanomolar Potency
149. 1qbs: Hiv-1 Protease Inhibitors Wiih Low Nanomolar Potency
150. 1qbt: Hiv-1 Protease Inhibitors Wiih Low Nanomolar Potency
151. 1qbu: Hiv-1 Protease Inhibitors Wiih Low Nanomolar Potency
152. 3hdk: Crystal Structure of Chemically Synthesized [aib51/51']hiv-1 Protease
153. 3hbo: Crystal Structure of Chemically Synthesized [d-ala51/51']hiv-1 Protease
154. 3h5b: Crystal Structure of Wild Type Hiv-1 Protease with Novel P1'-ligand Grl-02031
155. 1rl8: Crystal Structure of The Complex of Resistant Strain of Hiv- 1 PROTEASE(V82A Mutant) with Ritonavir
156. 1rpi: Crystal Structures of a Multidrug-resistant Hiv-1 Protease Reveal an Expanded Active Site Cavity
157. 1rq9: Crystal Structures of a Multidrug-resistant Hiv-1 Protease Reveal an Expanded Active Site Cavity
158. 3ggu: Hiv Pr Drug Resistant Patient's Variant in Complex with Darunavir
159. 3ggt: Hiv Pr Drug Highly Resistant Patient's Variant in Complex with Darunavir
160. 1rv7: Crystal Structures of a Multidrug-resistant Hiv-1 Protease Reveal an Expanded Active Site Cavity
161. 3fx5: Structure of Hiv-1 Protease in Complex with Potent Inhibitor Kni-272 Determined by High Resolution X-ray Crystallography
162. 3fsm: Crystal Structure of a Chemically Synthesized 203 Amino Acid 'covalent Dimer' [l-ala51,d-ala51'] Hiv-1 Protease Molecule
163. 1sdt: Crystal Structures of Hiv Protease V82A and L90M Mutants Reveal Changes in Indinavir Binding Site.
164. 1sdu: Crystal Structures of Hiv Protease V82A and L90M Mutants Reveal Changes in Indinavir Binding Site.
165. 1sdv: Crystal Structures of Hiv Protease V82A and L90M Mutants Reveal Changes in Indinavir Binding Site.
166. 1sgu: Comparing The Accumulation of Active Site and Non-active Site Mutations in The Hiv-1 Protease
167. 1sh9: Comparing The Accumulation of Active Site and Non-active Site Mutations in The Hiv-1 Protease
168. 3fiv: Crystal Structure of Feline Immunodeficiency Virus Protease Complexed with a Substrate
169. 1sp5: Crystal Structure of Hiv-1 Protease Complexed with a Product of Autoproteolysis
170. 1t3r: Hiv Protease Wild-type in Complex with Tmc114 Inhibitor
171. 1t7i: The Structural and Thermodynamic Basis for The Binding of Tmc114, a Next-generation Hiv-1 Protease Inhibitor.
172. 1t7j: Crystal Structure of Inhibitor Amprenavir in Complex with a Multi-drug Resistant Variant of Hiv-1 Protease (L63P/V82T/I84V)
173. 1t7k: Crystal Structure of Hiv Protease Complexed with Arylsulfonamide Azacyclic Urea
174. 3em6: Crystal Structure of I50L/A71V Mutant of Hiv-1 Protease in Complex with Inhibitor Darunavir
175. 3em4: Crystal Structure of Atazanavir (atv) in Complex with I50L/A71V Drug-resistant Hiv-1 Protease
176. 3em3: Crystal Structure of Amprenavir (apv) in Complex with a Drug Resistant Hiv-1 Protease Variant (I50L/A71V).
177. 1tcw: Siv Protease Complexed with Inhibitor Sb203386
178. 1tcx: Hiv Triple Mutant Protease Complexed with Inhibitor Sb203386
179. 3el9: Crystal Structure of Atazanavir (atv) in Complex with a Multidrug Hiv-1 Protease (V82T/I84V)
180. 3el4: Crystal Structure of Inhibitor Saquinavir (sqv) Complexed with The Multidrug Hiv-1 Protease Variant L63P/V82T/I84V
181. 3el1: Crystal Structure of Wild-type Hiv Protease in Complex with The Inhibitor, Atazanavir
182. 3el0: Crystal Structure of The Inhibitor Nelfinavir (nfv) in Complex with a Multi-drug Resistant Hiv-1 Protease Variant (L10I/G48V/I54V/V64I/V82A) (refer: Flap+ in Citation)
183. 3eky: Crystal Structure of Wild-type Hiv Protease in Complex with The Inhibitor, Atazanavir
184. 3ekx: Crystal Structure of The Wild-type Hiv-1 Protease with The Inhibitor, Nelfinavir
185. 3ekw: Crystal Structure of The Inhibitor Atazanavir (atv) in Complex with a Multi-drug Resistance Hiv-1 Protease Variant (L10I/G48V/I54V/V64I/V82A) Refer: Flap+ in Citation.
186. 3ekv: Crystal Structure of The Wild Type Hiv-1 Protease with The Inhibitor, Amprenavir
187. 3ekt: Crystal Structure of The Inhibitor Darunavir (drv) in Complex with a Multi-drug Resistant Hiv-1 Protease Variant (L10F/G48V/I54V/V64I/V82A) (refer: Flap+ in Citation.)
188. 3ekq: Crystal Structure of Inhibitor Saquinavir (sqv) in Complex with Multi-drug Resistant Hiv-1 Protease (L63P/V82T/I84V) (referred to as Act in Paper)
189. 3ekp: Crystal Structure of The Inhibitor Amprenavir (apv) in Complex with a Multi-drug Resistant Hiv-1 Protease Variant (L10I/G48V/I54V/V64I/V82A)REFER: Flap+ in Citation
190. 1tsq: Crystal Structure of AP2V Substrate Variant of Nc-p1 Decamer Peptide in Complex with V82A/D25N Hiv-1 Protease Mutant
191. 1tsu: Crystal Structure of Decamer Ncp1 Substrate Peptide in Complex with Wild-type D25N Hiv-1 Protease Variant
192. 1tw7: Wide Open 1.3a Structure of a Multi-drug Resistant Hiv-1 Protease Represents a Novel Drug Target
193. 3dox: X-ray Structure of Hiv-1 Protease in Situ Product Complex
194. 1u8g: Crystal Structure of a Hiv-1 Protease in Complex with Peptidomimetic Inhibitor Ki2-phe-glu-glu-nh2
195. 3dk1: Wild Type Hiv-1 Protease with Potent Antiviral Inhibitor Grl-0105a
196. 3djk: Wild Type Hiv-1 Protease with Potent Antiviral Inhibitor Grl-0255a
197. 3dcr: X-ray Structure of Hiv-1 Protease and Hydrated Form of Ketomethylene Isostere Inhibitor
198. 3dck: X-ray Structure of D25N Chemical Analogue of Hiv-1 Protease Complexed with Ketomethylene Isostere Inhibitor
199. 3d3t: Crystal Structure of Hiv-1 Crf01_ae in Complex with The Substrate P1-p6
200. 3d20: Crystal Structure of Hiv-1 Mutant I54V and Inhibitor Darunavia
201. 3d1z: Crystal Structure of Hiv-1 Mutant I54M and Inhibitor Darunavir
202. 3d1y: Crystal Structure of Hiv-1 Mutant I54V and Inhibitor Saquina
203. 3d1x: Crystal Structure of Hiv-1 Mutant I54M and Inhibitor Saquinavir
204. 3cyx: Crystal Structure of Hiv-1 Mutant I50V and Inhibitor Saquinavira
205. 3cyw: Effect of Flap Mutations on Structure of Hiv-1 Protease and Inhibition by Saquinavir and Darunavir
206. 3ckt: Hiv-1 Protease in Complex with a Dimethylallyl Decorated Pyrrolidine Based Inhibitor (orthorombic Space Group)
207. 1vij: Hiv-1 Protease Complexed with The Inhibitor Hoe/bay 793 Hexagonal Form
208. 1vik: Hiv-1 Protease Complexed with The Inhibitor Hoe/bay 793 Orthorhombic Form
209. 3bxs: Crystal Structures of Highly Constrained Substrate and Hydrolysis Products Bound to Hiv-1 Protease. Implications for Catalytic Mechanism
210. 3bxr: Crystal Structures of Highly Constrained Substrate and Hydrolysis Products Bound to Hiv-1 Protease. Implications for Catalytic Mechanism
211. 3bvb: Cystal Structure of Hiv-1 Active Site Mutant D25N and Inhibitor Darunavir
212. 3bva: Cystal Structure of Hiv-1 Active Site Mutant D25N and P2-nc Analog Inhibitor
213. 3bhe: Hiv-1 Protease in Complex with a Three Armed Pyrrolidine Derivative
214. 3bgc: Hiv-1 Protease in Complex with a Benzyl Decorated Oligoamine
215. 3bgb: Hiv-1 Protease in Complex with a Isobutyl Decorated Oligoamine
216. 1w5v: Hiv-1 Protease in Complex with Fluoro Substituted Diol- Based C2-symmetric Inhibitor
217. 1w5w: Hiv-1 Protease in Complex with Fluoro Substituted Diol- Based C2-symmetric Inhibitor
218. 1w5x: Hiv-1 Protease in Complex with Fluoro Substituted Diol- Based C2-symmetric Inhibitor
219. 1w5y: Hiv-1 Protease in Complex with Fluoro Substituted Diol- Based C2-symmetric Inhibitor
220. 3bc4: I84V Hiv-1 Protease in Complex with a Pyrrolidine Diester
221. 3b80: Hiv-1 Protease Mutant I54V Complexed with Gem-diol-amine Intermediate Nlltqi
222. 3b7v: Hiv-1 Protease Complexed with Gem-diol-amine Tetrahedral Intermediate Nlltqi
223. 3aid: A New Class of Hiv-1 Protease Inhibitor: The Crystallographic Structure, Inhibition and Chemical Synthesis of an Aminimide Peptide Isostere
224. 3a2o: Crystal Structure of Hiv-1 Protease Complexed with Kni-1689
225. 2zye: Structure of Hiv-1 Protease in Complex with Potent Inhibitor Kni-272 Determined by Neutron Crystallography
226. 2zga: Hiv-1 Protease in Complex with a Dimethylallyl Decorated Pyrrolidine Based Inhibitor (hexagonal Space Group)
227. 2z54: The Influence of I47A Mutation on Reduced Susceptibility to The Protease Inhibitor Lopinavir
228. 2z4o: Wild Type Hiv-1 Protease with Potent Antiviral Inhibitor Grl-98065
229. 1xl2: Hiv-1 Protease in Complex with Pyrrolidinmethanamine
230. 1xl5: Hiv-1 Protease in Complex with Amidhyroxysulfone
231. 2wl0: Hiv-1 Protease Inhibitors Containing a Tertiary Alcohol in The Transition-state Mimic with Improved Cell-based Antiviral Activity
232. 2wkz: Hiv-1 Protease Inhibitors Containing a Tertiary Alcohol in The Transition-state Mimic with Improved Cell-based Antiviral Activity
233. 1ytg: Siv Protease Crystallized with Peptide Product
234. 1yth: Siv Protease Crystallized with Peptide Product
235. 1yti: Siv Protease Crystallized with Peptide Product
236. 1ytj: Siv Protease Crystallized with Peptide Product
237. 2whh: Hiv-1 Protease Tethered Dimer Q-product Complex along with Nucleophilic Water Molecule
238. 1z1h: Hiv-1 Protease Complexed with Macrocyclic Peptidomimetic Inhibitor 3
239. 1z1r: Hiv-1 Protease Complexed with Macrocyclic Peptidomimetic Inhibitor 2
240. 1z8c: Crystal Structure of The Complex of Mutant Hiv-1 Protease (L63P, A71V, V82T, I84V) with a Hydroxyethylamine Peptidomimetic Inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE- Glu-phe-nh2
241. 1zbg: Crystal Structure of a Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with a Hydroxyethylamine Peptidomimetic Inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
242. 1zj7: Crystal Structure of a Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with a Hydroxyethylamine Peptidomimetic Inhibitor BOC-PHE-PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
243. 1zlf: Crystal Structure of a Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with a Hydroxyethylamine Peptidomimetic Inhibitor
244. 1zp8: Hiv Protease with Inhibitor Ab-2
245. 1zpa: Hiv Protease with Scripps Ab-3 Inhibitor
246. 1zpk: Crystal Structure of The Complex of Mutant Hiv-1 Protease (A71V, V82T, I84V) with a Hydroxyethylamine Peptidomimetic Inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
247. 1zsf: Crystal Structure of Complex of a Hydroxyethylamine Inhibitor with Hiv-1 Protease at 2.0a Resolution
248. 1zsr: Crystal Structure of Wild Type Hiv-1 Protease (bru Isolate) with a Hydroxyethylamine Peptidomimetic Inhibitor Boc-phe- PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
249. 1ztz: Crystal Structure of Hiv Protease- Metallacarborane Complex
250. 2a1e: High Resolution Structure of Hiv-1 Pr with Ts-126
251. 2a4f: Synthesis and Activity of N-axyl Azacyclic Urea Hiv-1 Protease Inhibitors with High Potency against Multiple Drug Resistant Viral Strains.
252. 2aid: Structure of a Non-peptide Inhibitor Complexed with Hiv-1 Protease: Developing a Cycle of Structure-based Drug Design
253. 2aoc: Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with a Substrate Analog P2-nc
254. 2aod: Crystal Structure Analysis of Hiv-1 Protease with a Substrate Analog P2-nc
255. 2aoe: Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with a Substrate Analog Ca-p2
256. 2aof: Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with a Substrate Analog P1-p6
257. 2aog: Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with a Substrate Analog P2-nc
258. 2aoh: Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with a Substrate Analog P6-pr
259. 2aoi: Crystal Structure Analysis of Hiv-1 Protease with a Substrate Analog P1-p6
260. 2aoj: Crystal Structure Analysis of Hiv-1 Protease with a Substrate Analog P6-pr
261. 2uy0: Two-carbon-elongated Hiv-1 Protease Inhibitors with a Tertiary-alcohol-containing Transition-state Mimic
262. 2uxz: Two-carbon-elongated Hiv-1 Protease Inhibitors with a Tertiary-alcohol-containing Transition-state Mimic
263. 2aqu: Structure of Hiv-1 Protease Bound to Atazanavir
264. 2avm: Kinetics, Stability, and Structural Changes in High Resolution Crystal Structures of Hiv-1 Protease with Drug Resistant Mutations L24I, I50V, and G73S
265. 2avo: Kinetics, Stability, and Structural Changes in High Resolution Crystal Structures of Hiv-1 Protease with Drug Resistant Mutations L24I, I50V, and G73S
266. 2avq: Kinetics, Stability, and Structural Changes in High Resolution Crystal Structures of Hiv-1 Protease with Drug Resistant Mutations L24I, I50V, and G73S
267. 2avs: Kinetics, Stability, and Structural Changes in High Resolution Crystal Structures of Hiv-1 Protease with Drug Resistant Mutations L24I, I50V, and G73S
268. 2avv: Kinetics, Stability, and Structural Changes in High Resolution Crystal Structures of Hiv-1 Protease with Drug Resistant Mutations L24I, I50V, and G73S
269. 2upj: Hiv-1 Protease Complex with U100313 ([3-[[3-[cyclopropyl [4- Hydroxy-2oxo-6-[1-(phenylmethyl)propyl]-2h-pyran-3-yl] Methyl]phenyl]amino]-3-oxo-propyl]carbamic Acid Tert-butyl Ester)
270. 2az8: Hiv-1 Protease Nl4-3 in Complex with Inhibitor, Tl-3
271. 2az9: Hiv-1 Protease Nl4-3 1x Mutant
272. 2azb: Hiv-1 Protease Nl4-3 3x Mutant in Complex with Inhibitor, Tl-3
273. 2azc: Hiv-1 Protease Nl4-3 6x Mutant
274. 2bb9: Structure of Hiv1 Protease and AKC4P_133A Complex.
275. 2bbb: Structure of Hiv1 Protease and Hh1_173_3a Complex.
276. 2rkg: Hiv-1 Pr Resistant Mutant + Lpv
277. 2rkf: Hiv-1 Pr Resistant Mutant + Lpv
278. 2bqv: Hiv-1 Protease in Complex with Inhibitor Aha455
279. 2r43: I50V Hiv-1 Protease in Complex with an Amino Decorated Pyrrolidine-based Inhibitor
280. 2r3w: I84V Hiv-1 Protease in Complex with a Amino Decorated Pyrrolidine-based Inhibitor
281. 2r3t: I50V Hiv-1 Protease Mutant in Complex with a Carbamoyl Decorated Pyrrolidine-based Inhibitor
282. 2r38: I84V Hiv-1 Protease Mutant in Complex with a Carbamoyl Decorated Pyrrolidine-based Inhibitor
283. 2qnq: Hiv-1 Protease in Complex with a Chloro Decorated Pyrrolidine-based Inhibitor
284. 2qnp: Hiv-1 Protease in Complex with a Iodo Decorated Pyrrolidine- Based Inhibitor
285. 2qnn: Hiv-1 Protease in Complex with a Multiple Decorated Pyrrolidine-based Inhibitor
286. 2qmp: Crystal Structure of Hiv-1 Protease Complexed with Pl-100
287. 2cej: P1' Extended Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol in The Transition-state Mimicking Scaffold
288. 2cem: P1' Extended Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol in The Transition-state Mimicking Scaffold
289. 2cen: P1' Extended Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol in The Transition-state Mimicking Scaffold
290. 2qhc: The Influence of I47A Mutation on Reduced Susceptibility to The Protease Inhibitor Lopinavir
291. 2qd8: Hiv-1 Protease Mutant I84V with Potent Antiviral Inhibitor Grl-98065
292. 2qd7: Hiv-1 Protease Mutant V82A with Potent Antiviral Inhibitor Grl-98065
293. 2qd6: Hiv-1 Protease Mutant I50V with Potent Antiviral Inhibitor Grl-98065
294. 2qci: Hiv-1 Protease Mutant D30N with Potent Antiviral Inhibitor Grl-98065
295. 2qak: Hiv-1 Pr Mutant in Complex with Nelfinavir
296. 2q64: Hiv-1 Pr Mutant in Complex with Nelfinavir
297. 2q63: Hiv-1 Pr Mutant in Complex with Nelfinavir
298. 2pyn: Hiv-1 Pr Mutant in Complex with Nelfinavir
299. 2pym: Hiv-1 Pr Mutant in Complex with Nelfinavir
300. 2pwr: Hiv-1 Protease in Complex with a Carbamoyl Decorated Pyrrolidine-based Inhibitor
301. 2pwc: Hiv-1 Protease in Complex with a Amino Decorated Pyrrolidine-based Inhibitor
302. 2pqz: Hiv-1 Protease in Complex with a Pyrrolidine-based Inhibitor
303. 2pc0: Apo Wild-type Hiv Protease in The Open Conformation
304. 2p3d: Crystal Structure of The Multi-drug Resistant Mutant Subtype F Hiv Protease Complexed with Tl-3 Inhibitor
305. 2p3c: Crystal Structure of The Subtype F Wild Type Hiv Protease Complexed with Tl-3 Inhibitor
306. 2p3b: Crystal Structure of The Subtype B Wild Type Hiv Protease Complexed with Tl-3 Inhibitor
307. 2p3a: Crystal Structure of The Multi-drug Resistant Mutant Subtype B Hiv Protease Complexed with Tl-3 Inhibitor
308. 2o40: Crystal Structure of a Chemically Synthesized 203 Amino Acid 'covalent Dimer' Hiv-1 Protease Molecule
309. 2nxm: Structure of Hiv-1 Protease D25N Complexed with The Rt-rh Analogue Peptide Gly-ala-gln-thr-phe*tyr-val-asp-gly-ala
310. 2nxl: Structure of Hiv-1 Protease D25N Complexed with The Rt-rh Analogue Peptide Gly-ala-glu-val-phe*tyr-val-asp-gly-ala
311. 2nxd: Structure of Hiv-1 Protease D25N Complexed with Rt-rh Analogue Peptide Gly-ala-asp-ile-phe*tyr-leu-asp-gly-ala
312. 2nph: Crystal Structure of Hiv1 Protease in Situ Product Complex
313. 2nnp: Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with a Inhibitor Saquinavir
314. 2nnk: Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with a Inhibitor Saquinavir
315. 2nmz: Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with a Inhibitor Saquinavir
316. 2nmy: Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with a Inhibitor Saquinavir
317. 2f3k: Substrate Envelope and Drug Resistance: Crystal Structure of R01 in Complex with Wild-type Hiv-1 Protease
318. 2f80: Hiv-1 Protease Mutant D30N Complexed with Inhibitor Tmc114
319. 2f81: Hiv-1 Protease Mutant L90M Complexed with Inhibitor Tmc114
320. 2f8g: Hiv-1 Protease Mutant I50V Complexed with Inhibitor Tmc114
321. 2fdd: Crystal Structure of Hiv Protease D545701 Bound with Gw0385
322. 2fde: Wild Type Hiv Protease Bound with Gw0385
323. 2fgu: X-ray Crystal Structure of Hiv-1 Protease T80S Variant in Complex with The Inhibitor Saquinavir Used to Explore The Role of Invariant Thr80 in Hiv-1 Protease Structure, Function, and Viral Infectivity.
324. 2fgv: X-ray Crystal Structure of Hiv-1 Protease T80N Variant in Complex with The Inhibitor Saquinavir Used to Explore The Role of Invariant Thr80 in Hiv-1 Protease Structure, Function, and Viral Infectivity.
325. 2fiv: Crystal Structure of Feline Immunodeficiency Virus Protease Complexed with a Substrate
326. 2fmb: Eiav Protease Complexed with an Inhibitor Lp-130
327. 2fns: Crystal Structure of Wild-type Inactive (D25N) Hiv-1 Protease Complexed with Wild-type Hiv-1 Nc-p1 Substrate.
328. 2fnt: Crystal Structure of a Drug-resistant (V82A) Inactive (D25N) Hiv-1 Protease Complexed with AP2V Variant of Hiv-1 Nc-p1 Substrate.
329. 2fxd: X-ray Crystal Structure of Hiv-1 Protease Irm Mutant Complexed with Atazanavir (bms-232632)
330. 2fxe: X-ray Crystal Structure of Hiv-1 Protease Crm Mutant Complexed with Atazanavir (bms-232632)
331. 2g69: Structure of Unliganded Hiv-1 Protease F53L Mutant
332. 2hah: The Structure of Fiv 12s Protease in Complex with Tl-3
333. 2hb2: Structure of Hiv Protease 6x Mutant in Apo Form
334. 2hb4: Structure of Hiv Protease Nl4-3 in an Unliganded State
335. 2hc0: Structure of Hiv Protease 6x Mutant in Complex with Ab-2.
336. 2hs1: Ultra-high Resolution X-ray Crystal Structure of Hiv-1 Protease V32I Mutant with Tmc114 (darunavir) Inhibitor
337. 2hs2: Crystal Structure of M46L Mutant of Hiv-1 Protease Complexed with Tmc114 (darunavir)
338. 2i4d: Crystal Structure of Wt Hiv-1 Protease with Gs-8373
339. 2i4u: Hiv-1 Protease with Tmc-126
340. 2i4v: Hiv-1 Protease I84V, L90M with Tmc126
341. 2i4w: Hiv-1 Protease Wt with Gs-8374
342. 2i4x: Hiv-1 Protease I84V, L90M with Gs-8374
343. 2idw: Crystal Structure Analysis of Hiv-1 Protease Mutant V82A with a Potent Non-peptide Inhibitor (uic-94017)
344. 2ien: Crystal Structure Analysis of Hiv-1 Protease with a Potent Non-peptide Inhibitor (uic-94017)
345. 2ieo: Crystal Structure Analysis of Hiv-1 Protease Mutant I84V with a Potent Non-peptide Inhibitor (uic-94017)
346. 2jo0: The Solution Structure of The Monomeric Species of The C Terminal Domain of The Ca Protein of Hiv-1
347. 3oy4: Crystal Structure of Hiv-1 L76V Protease in Complex with The Protease Inhibitor Darunavir.
348. 3hau: Crystal Structure of Chemically Synthesized Hiv-1 Protease with Reduced Isostere Mvt-101 Inhibitor
349. 3haw: Crystal Structure of [l-ala51/51']hiv-1 Protease with Reduced Isostere Mvt-101 Inhibitor
350. 3hzc: Crystal Structure of a Chemically Synthesized 203 Amino Acid 'covalent Dimer' [gly51;aib51']hiv-1 Protease Molecule Complexed with Mvt-101 Reduced Isostere Inhibitor
351. 3i2l: Crystal Structure of a Chemically Synthesized [allo-ile50/50']hiv-1 Protease Molecule Complexed with Mvt-101 Reduced Isostere Inhibitor
352. 3iaw: Crystal Structure of a Chemically Synthesized 203 Amino Acid 'covalent Dimer' [gly51;aib51']hiv-1 Protease Molecule Complexed with Mvt-101 Reduced Isostere Inhibitor at 1.6 a Resolution
353. 3ka2: Crystal Structure of Chemically Synthesized 203 Amino Acid 'covalent Dimer' [l-ala;gly51']hiv-1 Protease Molecule Complexed with Mvt-101 Reduced Isostere Inhibitor at 1.4 a Resolution
354. 3mim: X-ray Snapshot of Hiv-1 Protease in Action: Observation of Tetrahedral Intermediate and Its Sihb with Catalytic Aspartate
355. 3mws: Crystal Structure of Group N Hiv-1 Protease
356. 3pwm: Hiv-1 Protease Mutant L76V with Darunavir
357. 3pwr: Hiv-1 Protease Mutant L76V Complexed with Saquinavir
358. 3qin: Crystal Structure of Hiv-1 Rnase H P15 with Engineered E. Coli Loop and Pyrimidinol Carboxylic Acid Inhibitor
359. 3qio: Crystal Structure of Hiv-1 Rnase H with Engineered E. Coli Loop and N- Hydroxy Quinazolinedione Inhibitor
360. 3qip: Structure of Hiv-1 Reverse Transcriptase in Complex with an Rnase H Inhibitor and Nevirapine
361. 3hlo: Crystal Structure of Chemically Synthesized 'covalent Dimer' [gly51/d- Ala51']hiv-1 Protease
362. 3ia9: Crystal Structure of a Chemically Synthesized [D25N]HIV-1 Protease Molecule Complexed with Mvt-101 Reduced Isostere Inhibitor
363. 3ndt: Hiv-1 Protease Saquinavir:ritonavir 1:1 Complex Structure
364. 3ndu: Hiv-1 Protease Saquinavir:ritonavir 1:5 Complex Structure
365. 3ndw: Hiv-1 Protease Saquinavir:ritonavir 1:15 Complex Structure
366. 3ndx: Hiv-1 Protease Saquinavir:ritonavir 1:50 Complex Structure
367. 3qoz: Structure of Wild-type Hiv Protease in Complex with Darunavir
368. 3gi0: Crystal Structure of a Chemically Synthesized 203 Amino Acid 'covalent Dimer' [l-ala51,d-ala51'] Hiv-1 Protease Molecule Complexed with Jg- 365 Inhibitor
369. 3st5: Crystal Structure of Wild-type Hiv-1 Protease with C3-substituted Hexahydrocyclopentafuranyl Urethane as P2-ligand, Grl-0489a
370. 3nls: Crystal Structure of Hiv-1 Protease in Complex with Kni-10772
371. 3oxv: Crystal Structure of Hiv-1 I50V, A71 Protease in Complex with The Protease Inhibitor Amprenavir.
372. 3oxw: Crystal Structure of Hiv-1 I50V, A71V Protease in Complex with The Protease Inhibitor Darunavir
373. 3oxx: Crystal Structure of Hiv-1 I50V, A71V Protease in Complex with The Protease Inhibitor Atazanavir
374. 3th9: Crystal Structure of Hiv-1 Protease Mutant Q7K V32I L63I with a Cyclic Sulfonamide Inhibitor
375. 3so9: Darunavir in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
376. 3spk: Tipranavir in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
377. 3tam: Crystal Structure of Hiv-1 Reverse Transcriptase (K103N Mutant) in Complex with Inhibitor M06
378. 3nwq: X-ray Structure of Ester Chemical Analogue [o-ile50,o-ile50']hiv-1 Protease Complexed with Mvt-101
379. 3nwx: X-ray Structure of Ester Chemical Analogue [o-ile50,o-ile50']hiv-1 Protease Complexed with Kvs-1 Inhibitor
380. 3nxe: X-ray Structure of Ester Chemical Analogue 'covalent Dimer' [ile50,o- Ile50']hiv-1 Protease Complexed with Mvt-101 Inhibitor
381. 3nxn: X-ray Structure of Ester Chemical Analogue 'covalent Dimer' [ile50,o- Ile50']hiv-1 Protease Complexed with Kvs-1 Inhibitor
382. 3nyg: X-ray Structure of Ester Chemical Analogue [o-gly51,o-gly51']hiv-1 Protease Complexed with Mvt-101 Inhibitor
383. 2xye: Hiv-1 Inhibitors with a Tertiary-alcohol-containing Transition-state Mimic and Various P2 and P1 Prime Substituents
384. 2xyf: Hiv-1 Inhibitors with a Tertiary-alcohol-containing Transition-state Mimic and Various P2 and P1 Prime Substituents
385. 3psu: Hiv-1 Protease in Complex with an Isobutyl Decorated Oligoamine (symmetric Binding Mode)
386. 3qaa: Hiv-1 Wild Type Protease with a Substituted Bis-tetrahydrofuran Inhibitor, Grl-044-10a
387. 3qbf: Hiv-1 Protease (mutant Q7K L33I L63I) in Complex with a Three-armed Pyrrolidine-based Inhibitor
388. 3u7s: Hiv Pr Drug Resistant Patient's Variant in Complex with Darunavir
389. 3qih: Hiv-1 Protease (mutant Q7K L33I L63I) in Complex with a Novel Inhibitor
390. 3qn8: Hiv-1 Protease (mutant Q7K L33I L63I) in Complex with a Novel Inhibitor