EC 3.4.23.46 - memapsin 2

3D structures of EC 3.4.23.46 - memapsin 2 in Protein Data Bank

updated: 9 February 2012, 15:47

1. 1fkn: Structure of Beta-secretase Complexed with Inhibitor
2. 3nsh: Bace-1 in Complex with Eln475957
3. 3n4l: Bace-1 in Complex with Eln380842
4. 3msm: Fragment Based Discovery and Optimisation of Bace-1 Inhibitors
5. 3msl: Fragment Based Discovery and Optimisation of Bace-1 Inhibitors
6. 3msk: Fragment Based Discovery and Optimisation of Bace-1 Inhibitors
7. 3msj: Structure of Bace (beta Secretase) in Complex with Inhibitor
8. 3lpk: Structure of Bace Bound to Sch747123
9. 3lpj: Structure of Bace Bound to Sch743641
10. 3lpi: Structure of Bace Bound to Sch745132
11. 3lnk: Structure of Bace Bound to Sch743813
12. 3lhg: Bace1 in Complex with The Aminohydantoin Compound 4g
13. 3l5f: Structure of Bace Bound to Sch736201
14. 3l5e: Structure of Bace Bound to Sch736062
15. 3l5d: Structure of Bace Bound to Sch723873
16. 3l5c: Structure of Bace Bound to Sch723871
17. 3l5b: Structure of Bace Bound to Sch713601
18. 3l59: Structure of Bace Bound to Sch710413
19. 3l58: Structure of Bace Bound to Sch589432
20. 3l3a: Bace-1 with The Aminopyridine Compound 32
21. 3l38: Bace1 in Complex with The Aminopyridine Compound 44
22. 3kn0: Structure of Bace Bound to Sch708236
23. 3kmy: Structure of Bace Bound to Sch12472
24. 3kmx: Structure of Bace Bound to Sch346572
25. 3k5g: Human Bace-1 Complex with Bjc060
26. 3k5f: Human Bace-1 Complex with Ayh011
27. 3k5d: Crystal Structure of Bace-1 in Complex with Ahm178
28. 3k5c: Human Bace-1 Complex with Nb-216
29. 3ixk: Potent Beta-secretase 1 Inhibitor
30. 3ixj: Crystal Structure of Beta-secretase 1 in Complex with Selective Beta-secretase 1 Inhibitor
31. 3ivi: Design and Synthesis of Potent Bace-1 Inhibitors with Cellular Activity: Structure-activity Relationship of P1 Substituents
32. 3ivh: Design and Synthesis of Potent Bace-1 Inhibitors with Cellular Activity: Structure-activity Relationship of P1 Substituents
33. 3inh: Bace1 with The Aminohydantoin Compound R-58
34. 3inf: Bace1 with The Aminohydantoin Compound 37
35. 3ine: Bace1 with The Aminohydantoin Compound S-34
36. 3ind: Bace1 with The Aminohydantoin Compound 29
37. 3in4: Bace1 with Compound 38
38. 3in3: Bace1 with Compound 30
39. 3igb: Bace-1 with Compound 3
40. 3i25: Potent Beta-secretase 1 Hydroxyethylene Inhibitor
41. 3hw1: Structure of Bace (beta Secretase) in Complex with Ligand Ev2
42. 3hvg: Structure of Bace (beta Secretase) in Complex with Ev0
43. 3h0b: Discovery of Aminoheterocycles as a Novel Beta-secretase Inhibitor Class
44. 1sgz: Crystal Structure of Unbound Beta-secretase Catalytic Domain.
45. 3fkt: Crystal Structure of Human Beta Secretase Complexed with Spiropiperdine Iminohydantoin Inhibitor
46. 3exo: Crystal Structure of Bace1 Bound to Inhibitor
47. 1tqf: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
48. 3dv5: Crystal Structure of Human Beta-secretase in Complex with Nvp-bav544
49. 3dv1: Crystal Structure of Human Beta-secretase in Complex with Nvp-arv999
50. 3duy: Crystal Structure of Human Beta-secretase in Complex with Nvp-afj144
51. 3dm6: Beta-secretase 1 Complexed with Statine-based Inhibitor
52. 3ckr: Crystal Structure of Bace-1 in Complex with Inhibitor
53. 3ckp: Crystal Structure of Bace-1 in Complex with Inhibitor
54. 3cid: Structure of Bace Bound to Sch726222
55. 3cic: Structure of Bace Bound to Sch709583
56. 3cib: Structure of Bace Bound to Sch727596
57. 3buh: Bace-1 Complexed with Compound 4
58. 3bug: Bace-1 Complexed with Compound 3
59. 3buf: Bace-1 Complexed with Compound 2
60. 3bra: Bace-1 Complexed with Compound 1
61. 1w50: Apo Structure of Bace (beta Secretase)
62. 1w51: Bace (beta Secretase) in Complex with a Nanomolar Non- Peptidic Inhibitor
63. 2zjn: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)- Piperidin-4-yl]-2-(2-methyl-4-sulfamoyl-phenoxy)-acetamide
64. 2zjm: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with N-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)- Piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide
65. 2zjl: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with N-[1-(5-bromo-2,3-dimethoxy-benzyl)-piperidin- 4-yl]-4-mercapto-butyramide
66. 2zjk: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic Acid(3-mercapto-propyl)-amide
67. 2zjj: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic Acid (2-mercapto-ethyl)-amide
68. 2zji: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with N-[1-(2,6-dimethoxy-benzyl)-piperidin-4-yl]-4- Mercapto-butyramide
69. 2zjh: Crystal Structure of The Human Bace1 Catalytic Domain in Complex with N-(1-benzyl-piperidin-4-yl)-4-mercapto- Butyramide
70. 2zhv: Crystal Structure of Bace1 at Ph 7.0
71. 2zhu: Crystal Structure of Bace1 at Ph 5.0
72. 2zht: Crystal Structure of Bace1 at Ph 4.5
73. 2zhs: Crystal Structure of Bace1 at Ph 4.0
74. 2zhr: Crystal Structure of Bace1 in Complex with Om99-2 at Ph 5.0
75. 2ze1: X-ray Structure of Bace-1 in Complex with Compound 6g
76. 2zdz: X-ray Structure of Bace-1 in Complex with Compound 3.b.10
77. 1xn2: New Substrate Binding Pockets for Beta-secretase.
78. 1xn3: Crystal Structure of Beta-secretase Bound to a Long Inhibitor with Additional Upstream Residues.
79. 1xs7: Crystal Structure of a Cycloamide-urethane-derived Novel Inhibitor Bound to Human Brain Memapsin 2 (beta-secretase).
80. 2xfk: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(ethylamino)-5-((methylsulfonyl)( Phenyl)amino)benzamide
81. 2xfj: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1- Pyrrolidinyl)benzamide
82. 2xfi: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-((methylsulfonyl)(phenyl)amino) Benzamide
83. 1ym2: Crystal Structure of Human Beta Secretase Complexed with Nvp-aur200
84. 1ym4: Crystal Structure of Human Beta Secretase Complexed with Nvp-amk640
85. 2wjo: Human Bace (beta Secretase) in Complex with Cyclohexanecarboxylic Acid (2-(2-am Ino-6-phenoxy-4h- Quinazolin-3-yl)-2-cyclohexyl-ethyl)-amide
86. 2wf4: Human Bace-1 in Complex with 6-ethyl-1-methyl-n-((1s)-2-oxo- 1-(phenylmethyl)-3-(tetrahydro-2h-pyran-4-ylamino)propyl)- 1,3,4,6-tetrahydro(1,2)thiazepino(5,4,3-cd)indole-8- Carboxamide 2,2-dioxide
87. 2wf3: Human Bace-1 in Complex with 6-(ethylamino)-n-((1s,2r)-2- Hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-( Phenylmethyl)propyl)-1-methyl-1,3,4,5-tetrahydro-2,1- Benzothiazepine-8-carboxamide 2,2-dioxide
88. 2wf2: Human Bace-1 in Complex with 8-ethyl-n-((1s,2r)-2-hydroxy-3- (((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl) Propyl)-1-methyl-3,4,7,8-tetrahydro-1h,6h-(1,2,5) Thiadiazepino(5,4,3-de)quinoxaline-10-carboxamide 2,2- Dioxide
89. 2wf1: Human Bace-1 in Complex with 7-ethyl-n-((1s,2r)-2-hydroxy-3- (((3-(methyloxy)phenyl(methyl)amino)-1-(phenylmethyl) Propyl)-1-methyl-3,4-dihydro-1h-(1,2,5)thiadiazepino(3,4,5- Hi)indole-9-carboxamide 2,2-dioxide
90. 2wf0: Human Bace-1 in Complex with 4-ethyl-n-((1s,2r)-2-hydroxy-1- (phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino) Propyl)-8-(2-oxo-1-pyrrolidinyl)-6-quinolinecarboxamide
91. 2wez: Human Bace-1 in Complex with 1-ethyl-n-((1s,2r)-2-hydroxy-3- (((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl) Propyl)-4-(2-oxo-1-pyrrolidinyl)-1h-indole-6-carboxamide
92. 2vnn: Human Bace-1 in Complex with 7-ethyl-n-((1s,2r)-2-hydroxy-1- (phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino) Propyl)-1-methyl-3,4-dihydro-1h-(1,2,5)thiadiazepino(3,4,5- Hi)indole-9-carboxamide 2,2-dioxide
93. 2vnm: Human Bace-1 in Complex with 3-(1,1-dioxidotetrahydro-2h-1, 2-thiazin-2-yl)-5-(ethylamino)-n-((1s,2r)-2-hydroxy-1-( Phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino) Propyl)benzamide
94. 2vj9: Human Bace-1 in Complex with N-((1s,2r)-3-(cyclohexylamino)- 2-hydroxy-1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo- 1-pyrrolidinyl)benzamide
95. 2vj7: Human Bace-1 in Complex with 3-(ethylamino)-n-((1s,2r)-2- Hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl) Methyl)amino)propyl)-5-(2-oxo-1-pyrrolidinyl)benzamide
96. 2vj6: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1- Pyrrolidinyl)benzamide
97. 2viz: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(2-oxo-1-pyrrolidinyl)-5-(propyloxy) Benzamide
98. 2viy: Human Bace-1 in Complex with N-((1s,2r)-3-(((1s)-2-( Cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( Phenylmethyl)propyl)-3-(pentylsulfonyl)benzamide
99. 2vij: Human Bace-1 in Complex with 3-(1,1-dioxidotetrahydro-2h-1, 2-thiazin-2-yl)-5-(ethylamino)-n-((1s,2r)-2-hydroxy-1-( Phenylmethyl)-3-(1,2,3,4-tetrahydro-1-naphthalenylamino) Propyl)benzamide
100. 2vie: Human Bace-1 in Complex with N-((1s,2r)-1-benzyl-2-hydroxy- 3-((1,1,5-trimethylhexyl)amino)propyl)-3-(ethylamino)-5-(2- Oxopyrrolidin-1-yl)benzamide
101. 2va7: X-ray Crystal Structure of Beta Secretase Complexed with Compound 27
102. 2va6: X-ray Crystal Structure of Beta Secretase Complexed with Compound 24
103. 2va5: X-ray Crystal Structure of Beta Secretase Complexed with Compound 8c
104. 2b8l: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
105. 2b8v: Crystal Structure of Human Beta-secretase Complexed with L- L000430,469
106. 2qzl: Crystal Structure of Human Beta Secretase Complexed with Ixs
107. 2qzk: Crystal Structure of Human Beta Secretase Complexed with I21
108. 2qu3: Bace1 with Compound 2
109. 2qu2: Bace1 with Compound 1
110. 2qp8: Structure of Bace Bound to Sch734723
111. 2qmg: Structure of Bace Bound to Sch745966
112. 2qmf: Structure of Bace Bound to Sch735310
113. 2qmd: Structure of Bace Bound to Sch722924
114. 2qk5: Structure of Bace1 Bound to Sch626485
115. 2q15: Structure of Bace Complexed to Compound 3a
116. 2q11: Structure of Bace Complexed to Compound 1
117. 2ph8: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
118. 2ph6: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
119. 2p8h: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
120. 2p83: Potent and Selective Isophthalamide S2 Hydroxyethylamine Inhibitor of Bace1
121. 2p4j: Crystal Structure of Beta-secretase Bond to an Inhibitor with Isophthalamide Derivatives at P2-p3
122. 2ohu: X-ray Crystal Structure of Beta Secretase Complexed with Compound 8b
123. 2oht: X-ray Crystal Structure of Beta Secretase Complexed with Compound 7
124. 2ohs: X-ray Crystal Structure of Beta Secretase Complexed with Compound 6b
125. 2ohr: X-ray Crystal Structure of Beta Secretase Complexed with Compound 6a
126. 2ohq: X-ray Crystal Structure of Beta Secretase Complexed with Compound 4
127. 2ohp: X-ray Crystal Structure of Beta Secretase Complexed with Compound 3
128. 2ohn: X-ray Crystal Structure of Beta Secretase Complexed with 4- (4-fluorobenzyl)piperidine
129. 2ohm: X-ray Crystal Structure of Beta Secretase Complexed with N~3~-benzylpyridine-2,3-diamine
130. 2ohl: X-ray Crystal Structure of Beta Secretase Complexed with 2- Aminoquinoline
131. 2ohk: X-ray Crystal Structure of Beta Secretase Complexed with 1- Amino-isoquinoline
132. 2of0: X-ray Crystal Structure of Beta Secretase Complexed with Compound 5
133. 2oah: Crystal Structure of Human Beta Secretase Complexed with Inhibitor
134. 2ntr: Crystal Structure of Human Bace-1 Bound to Inhibitor
135. 2f3e: Crystal Structure of The Bace Complex with Axq093, a Macrocyclic Inhibitor
136. 2f3f: Crystal Structure of The Bace Complex with Bdf488, a Macrocyclic Inhibitor
137. 2fdp: Crystal Structure of Beta-secretase Complexed with an Amino- Ethylene Inhibitor
138. 2g94: Crystal Structure of Beta-secretase Bound to a Potent and Highly Selective Inhibitor.
139. 2hiz: Crystal Structure of Human Beta-secretase (bace) in The Presence of an Inhibitor
140. 2hm1: Crystal Structure of Human Beta-secretase (bace) in The Presence of an Inhibitor (2)
141. 2iqg: Crystal Structure of Hydroxyethyl Secondary Amine-based Peptidomimetic Inhibitor of Human Beta-secretase (bace)
142. 2irz: Crystal Structure of Human Beta-secretase Complexed with Inhibitor
143. 2is0: Crystal Structure of Human Beta-secretase Complexed with Inhibitor
144. 3kyr: Bace-1 in Complex with a Norstatine Type Inhibitor
145. 3ohf: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with Bms-655295 Aka N~3~-((1s,2r)-1- Benzyl-2-hydroxy-3-((3- Methoxybenzyl)amino)propyl)-n~1~, N~1~-dibutyl-1h-indole-1,3- Dicarboxamide
146. 3ohh: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with Bms-681889 Aka N~1~-butyl-5-cyano- N~3~-((1s,2r)-1-(3,5- Difluorobenzyl)-2-hydroxy-3-((3- Methoxybenzyl)amino)propyl)-n~1~- Methyl-1h-indole-1,3- Dicarboxamide
147. 3pi5: Crystal Structure of Human Beta Secretase in Complex with Bfg356
148. 3qbh: Structure Based Design, Synthesis and Sar of Cyclic Hydroxyethylamine (hea) Bace-1 Inhibitors
149. 3r1g: Structure Basis of Allosteric Inhibition of Bace1 by an Exosite- Binding Antibody
150. 3s2o: Fragment Based Discovery and Optimisation of Bace-1 Inhibitors
151. 3ooz: Bace1 in Complex with The Aminohydantoin Compound 102
152. 3r2f: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with Bms-693391 Aka (2s)-2-((3r)-3-acetamido-3-isobutyl-2-oxo-1- Pyrrolidinyl)-n-((1s,2r)-1-(3,5-difluorobenzyl)-2-hydroxy-2-((2r,4r)- 4-propoxy-2-pyrrolidinyl)ethyl)-4-phenylbutanamide
153. 3rsv: Structure of Bace-1 (beta-secretase) in Complex with (r)-3-(2-amino-6- O-tolylquinolin-3-yl)-n-((r)-2,2-dimethyltetrahydro-2h-pyran-4-yl)-2- Methylpropanamide
154. 3rsx: Structure of Bace-1 (beta-secretase) in Complex with 6-(thiophen-3- Yl)quinolin-2-amine
155. 3rth: Structure of Bace-1 (beta-secretase) in Complex with 6-(2-(3,3- Dimethylbut-1-ynyl)phenyl)quinolin-2-amine
156. 3rtm: Structure of Bace-1 (beta-secretase) in Complex with 3-(2- Aminoquinolin-3-yl)-n-cyclohexyl-n-methylpropanamide
157. 3rtn: Structure of Bace-1 (beta-secretase) in Complex with 3-(2-amino-6-o- Tolylquinolin-3-yl)-n-cyclohexylpropanamide
158. 3ru1: Structure of Bace-1 (beta-secretase) in Complex with 3-(2- Aminoquinolin-3-yl)-n-(cyclohexylmethyl)propanamide
159. 3rvi: Structure of Bace-1 (beta-secretase) in Complex with 2-((2-amino-6-o- Tolylquinolin-3-yl)methyl)-n-(cyclohexylmethyl)pentanamide
160. 3s7l: Pyrazolyl and Thienyl Aminohydantoins as Potent Bace1 Inhibitors
161. 3s7m: Pyrazolyl and Thienyl Aminohydantoins as Potent Bace1 Inhibitors
162. 3skf: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with (2s)-2-((3s)-3-(acetylamino)-3-(butan-2-yl)-2-oxopyrrolidin-1- Yl)-n-((2s,3r)-3-hydroxy-4-((3-methoxybenzyl)amino)-1-phenylbutan-2- Yl)-4-phenylbutanamide
163. 3skg: Crystal Structure of Beta-site App-cleaving Enzyme 1 (bace-wt) Complex with (2s)-2-((3r)-3-acetamido-3-isobutyl-2-oxo-1-pyrrolidinyl)-n- ((1s,2r)-1-(3,5-difluorobenzyl)-2-hydroxy-2-(1,2,3,4-tetrahydro-3- Isoquinolinyl)ethyl)-4-phenylbutanamide
164. 3u6a: Rational Design and Synthesis of Aminopiperazinones as Beta Secretase (bace) Inhibitors
165. 3tpj: Apo Structure of Bace1
166. 3tpl: Apo Structure of Bace1
167. 3tpp: Crystal Structure of Bace1 Complexed with an Inhibitor
168. 3tpr: Crystal Structure of Bace1 Complexed with an Inhibitor
169. 3ufl: Discovery of Pyrrolidine-based B-secretase Inhibitors: Lead Advancement through Conformational Design for Maintenance of Ligand Binding Efficiency